PMID- 22386832
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20131121
IS  - 1872-7131 (Electronic)
IS  - 0387-7604 (Linking)
VI  - 34
IP  - 10
DP  - 2012 Nov
TI  - Benign myoclonic epilepsy in infancy with preceding afebrile generalized 
      tonic-clonic seizures in Japan.
PG  - 829-33
LID - S0387-7604(12)00035-6 [pii]
LID - 10.1016/j.braindev.2012.02.003 [doi]
AB  - Benign myoclonic epilepsy in infancy (BMEI) is the youngest form of idiopathic 
      generalized epilepsy, characterized by myoclonic seizures (MS) in the first three 
      years of life in otherwise normal infants, and the lack of other seizure types 
      except for rare simple febrile seizures. Although afebrile generalized 
      tonic-clonic seizures (GTCS) have been described to develop later in the clinical 
      course of BMEI, mostly during adolescence, an association with GTCS in the early 
      stage of BMEI has never been recognized. We herein report seven children who 
      satisfied the criteria of BMEI except for the recurrence of GTCS before the onset 
      of MS. The age of onset and ictal video-polygraphic features of MS, as well as 
      the long-term seizure and developmental outcome in these children were similar to 
      those of children with typical BMEI. Furthermore, these GTCS mostly disappeared 
      within several months and were replaced by MS. Our study indicates that these 
      children may constitute a BMEI subgroup, expanding the spectrum of BMEI.
CI  - Copyright (c) 2012 The Japanese Society of Child Neurology. Published by Elsevier 
      B.V. All rights reserved.
FAU - Ito, Susumu
AU  - Ito S
AD  - Department of Pediatrics, School of Medicine, Tokyo Women's Medical University, 
      Shinjuku-ku, Japan. itos@ped.twmu.ac.jp
FAU - Oguni, Hirokazu
AU  - Oguni H
FAU - Osawa, Makiko
AU  - Osawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120303
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 0 (Anticonvulsants)
RN  - 5PE9FDE8GB (Clonazepam)
RN  - 5SEH9X1D1D (Ethosuximide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Anticonvulsants/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Clonazepam/therapeutic use
MH  - Electroencephalography
MH  - Epilepsies, Myoclonic/complications/drug therapy/*physiopathology
MH  - Ethosuximide/therapeutic use
MH  - Female
MH  - Humans
MH  - Infant
MH  - Japan
MH  - Male
MH  - Seizures/complications/drug therapy/*physiopathology
MH  - Treatment Outcome
MH  - Videotape Recording
MH  - Young Adult
EDAT- 2012/03/06 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/03/06 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2012/02/05 00:00 [revised]
PHST- 2012/02/07 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - S0387-7604(12)00035-6 [pii]
AID - 10.1016/j.braindev.2012.02.003 [doi]
PST - ppublish
SO  - Brain Dev. 2012 Nov;34(10):829-33. doi: 10.1016/j.braindev.2012.02.003. Epub 2012 
      Mar 3.