PMID- 22387569
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20141120
IS  - 1872-9711 (Electronic)
IS  - 0161-813X (Linking)
VI  - 33
IP  - 3
DP  - 2012 Jun
TI  - Behavioral effects following repeated exposure to hexachloronaphthalene in rats.
PG  - 361-9
LID - 10.1016/j.neuro.2012.02.011 [doi]
AB  - Polychlorinated naphthalenes (PCNs), including hexachloronaphthalene (HxCN), are 
      widespread global environmental contaminants. Our experiments were aimed at 
      assessing HxCN effects on motor behavior, long-term memory, pain sensitivity, 
      magnitude of stress-induced analgesia, auditory function and sensorimotor gating, 
      following repeated intragastric administration (28 days) of HxCN at 0.3 and 1.0 
      mg/kg body weight. Three weeks after the exposure termination, male Wistar rats 
      were subjected to the neurobehavioral tests battery performed in the following 
      order: open-field test, passive avoidance test, hot-plate test and acoustic 
      startle response test. Repeated administration of HxCN induced disorders of 
      motivational processes manifested by: anorectic effect caused by aphagia and 
      adipsia; significantly reduced motor activity (hypokinesia); impaired long-term 
      memory and acquired passive avoidance reaction; reduced pain threshold and 
      shortened duration of anxiety reaction after pain stimulus (sensory neglect). 
      Some of these neurobehavioral effects (impaired long-term memory, reduced pain 
      threshold and stress-induced analgesia) were observed at 0.3 mgHxCN/kg body 
      weight without any signs of overt toxicity. The outcome of our study shows that 
      HxCN, like other compounds of the persistent organic pollutants (POPs) group, 
      creates a potential risk of behavioral changes in the central nervous system in 
      the general population as a result of environmental exposure.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kilanowicz, Anna
AU  - Kilanowicz A
AD  - Department of Toxicology, Faculty of Pharmacy, Medical University, Lodz, Poland. 
      anna.kilanowicz@umed.lodz.pl
FAU - Wiaderna, Dorota
AU  - Wiaderna D
FAU - Lutz, Piotr
AU  - Lutz P
FAU - Szymczak, Wieslaw
AU  - Szymczak W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120225
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Environmental Pollutants)
RN  - 0 (Naphthalenes)
RN  - 58877-88-6 (1,2,3,4,5,6-hexachloronaphthalene)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Auditory Pathways/drug effects/physiopathology
MH  - Behavior, Animal/*drug effects
MH  - Central Nervous System/*drug effects/physiopathology
MH  - Environmental Pollutants/*toxicity
MH  - Male
MH  - Memory Disorders/chemically induced/psychology
MH  - Memory, Long-Term/drug effects
MH  - Motivation/drug effects
MH  - Motor Activity/drug effects
MH  - Naphthalenes/*toxicity
MH  - Neurotoxicity Syndromes/*etiology/physiopathology/psychology
MH  - Pain Threshold/drug effects
MH  - Perceptual Disorders/chemically induced/psychology
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/drug effects
MH  - Reflex, Startle/drug effects
MH  - Sensory Gating/drug effects
MH  - Time Factors
EDAT- 2012/03/06 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/03/06 06:00
PHST- 2011/10/10 00:00 [received]
PHST- 2012/02/06 00:00 [revised]
PHST- 2012/02/17 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - S0161-813X(12)00045-9 [pii]
AID - 10.1016/j.neuro.2012.02.011 [doi]
PST - ppublish
SO  - Neurotoxicology. 2012 Jun;33(3):361-9. doi: 10.1016/j.neuro.2012.02.011. Epub 
      2012 Feb 25.