PMID- 22391173
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 20
IP  - 1
DP  - 2012 Feb
TI  - [Characteristics of two cases of Burkitt lymphoma/leukemia with concurrent 
      t(8;14) and t(14;18)].
PG  - 93-6
AB  - This article aimed to report two cases of Burkitt lymphoma/leukemia with 
      concurrent t(8;14) and t(14;18). Morphology, immunophenotype, cytogenetics and 
      molecular biology (MICM) methods were applied to diagnosis. The results showed 
      that the two cases were both acute lymphocytic leukemia L3 type according to FAB 
      criteria. Conventional cytogenetic technique or interphase fluorescence in situ 
      hybridization (FISH) demonstrated that t(8;14) and t(14;18) were detected 
      concurrently in both patients. CD20, CD10, FMC7, CD38 and CD19 were expressed in 
      both patients by immunophenotyping. According to MICM, they were both diagnosed 
      as Burkitt lymphoma/leukemia. The first patient died in one month after 
      chemotherapy, and the second patient survived 19 months after rituximab- combined 
      high-dose chemotherapy and subsequently allogeneic hematopoietic stem cell 
      transplantation (HSCT). In conclusion, t(8;14) and t(14;18) may present 
      simultaneously in Burkitt lymphoma/leukemia and indicate poor prognosis. 
      Rituximab-combined chemotherapy and subsequently HSCT could improve the outcomes 
      of such cases.
FAU - Wang, Zheng
AU  - Wang Z
AD  - Peking University People Hospital, Peking University Institute of Hematology, 
      Beijing, China.
FAU - Lai, Yue-Yun
AU  - Lai YY
FAU - Feng, Lin
AU  - Feng L
FAU - Liu, Yan-Rong
AU  - Liu YR
FAU - Qin, Ya-Zhen
AU  - Qin YZ
FAU - Wang, Ya-Zhe
AU  - Wang YZ
FAU - Shi, Hong-Xia
AU  - Shi HX
FAU - Jiang, Qian
AU  - Jiang Q
FAU - Lu, Jin
AU  - Lu J
FAU - Huang, Xiao-Jun
AU  - Huang XJ
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - Burkitt Lymphoma/*genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Female
MH  - Humans
MH  - Lymphoma/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 2012/03/07 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/03/07 06:00
PHST- 2012/03/07 06:00 [entrez]
PHST- 2012/03/07 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
AID - 1009-2137(2012)01-0093-04 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Feb;20(1):93-6.