PMID- 22391175
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 20
IP  - 1
DP  - 2012 Feb
TI  - [Prognostic value of P53 aberrations in diffuse large B-cell lymphoma].
PG  - 100-2
AB  - The aim of this study was to analyze the P53 aberrations in diffuse large B-cell 
      lymphoma (DLBCL) and its prognostic value. Using fluorescence in situ 
      hybridization (FISH), the P53 gene was detected in paraffin-embedded tonsil 
      tissues from 50 cases of DLBCL, while all the peripheral blood of patients was 
      collected for detecting P53 protein in serum by using enzyme-linked immunosorbent 
      assay (ELISA). The relationships between P53 gene and protein expression and the 
      prognosis of patients with DLBCL were analyzed. The results showed that 21 out of 
      50 cases had P53 gene deletion, serum P53 protein content was (176.25 +/- 61.25) 
      pg/ml, which was higher than that in normal controls. The Cox model likelihood 
      ratio test found that abnormal P53 could be used as independent prognostic factor 
      in DLBCL patients. The risk of death in patients with P53 gene deletion were more 
      than that in patients with P53 gene normal. The patients with histology P53 gene 
      deletion detected by FISH also had relatively high level of mutant P53 protein in 
      serum. It is concluded that P53 aberrations in patients with DLBCL can be used as 
      an independent prognostic factor, the early detection of P53 in DLBCL patients 
      helps to determine their prognosis accurately.
FAU - Lu, Jing-Tao
AU  - Lu JT
AD  - Department of Hematology and Oncology, Nanjing Medical University, Changzhou, 
      Jiangsu Province, China.
FAU - Cen, Ling
AU  - Cen L
FAU - Zhou, Min
AU  - Zhou M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (TP53 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - Gene Deletion
MH  - *Genes, p53
MH  - Humans
MH  - Lymphoma, Large B-Cell, Diffuse/*diagnosis/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Tumor Suppressor Protein p53/*genetics
EDAT- 2012/03/07 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/03/07 06:00
PHST- 2012/03/07 06:00 [entrez]
PHST- 2012/03/07 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
AID - 1009-2137(2012)01-0100-03 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Feb;20(1):100-2.