PMID- 2239783
OWN - NLM
STAT- MEDLINE
DCOM- 19901221
LR  - 20180330
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 52
IP  - 6
DP  - 1990 Dec
TI  - Vitamin A status in preschool-age Indonesian children as assessed by the modified 
      relative-dose-response assay.
PG  - 1068-72
AB  - The modified relative-dose-response (MRDR) assay has been validated in rats as a 
      function of vitamin A status and tested in a group of American children. In this 
      study the MRDR assay was applied to West Javan children who are at risk of being 
      vitamin A deficient. Of 86 children enrolled, 75 were tested. In a time-course 
      study involving 22 children aged 3.7-5.3 y, blood samples were taken at different 
      times after doses of 0.35 mumol 3,4-didehydroretinyl acetate/kg body wt. 
      Generally, the ratio of dehydroretinol to retinol (DR-R ratio) peaked between 4 
      and 8 h. Thereafter, in a survey of 53 children aged 0.6-4.8 y, single blood 
      samples were drawn 5 h after the dehydroretinyl acetate dose. The DR-R ratio 
      ranged from 0.0028 to 0.169. With a DR-R ratio of 0.03 as the cutoff value, 62% 
      of the children were judged to be of marginal vitamin A status.
FAU - Tanumihardjo, S A
AU  - Tanumihardjo SA
AD  - Department of Biochemistry and Biophysics, Iowa State University, Ames 50011.
FAU - Muhilal
AU  - Muhilal
FAU - Yuniar, Y
AU  - Yuniar Y
FAU - Permaesih, D
AU  - Permaesih D
FAU - Sulaiman, Z
AU  - Sulaiman Z
FAU - Karyadi, D
AU  - Karyadi D
FAU - Olson, J A
AU  - Olson JA
LA  - eng
GR  - DK 32793/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 104621892X (vitamin A2)
RN  - 11103-57-4 (Vitamin A)
RN  - 4159-20-0 (3,4-didehydroretinoic acid)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Anthropometry
MH  - Child, Preschool
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Indonesia
MH  - Infant
MH  - *Nutritional Status
MH  - Time Factors
MH  - Tretinoin/*analogs & derivatives
MH  - Vitamin A/analogs & derivatives/*blood
MH  - Vitamin A Deficiency/*diagnosis
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - 10.1093/ajcn/52.6.1068 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 1990 Dec;52(6):1068-72. doi: 10.1093/ajcn/52.6.1068.