PMID- 22398509
OWN - NLM
STAT- MEDLINE
DCOM- 20120810
LR  - 20120410
IS  - 1423-033X (Electronic)
IS  - 0254-4962 (Linking)
VI  - 45
IP  - 3
DP  - 2012
TI  - Role of substance abuse comorbidity and personality on the outcome of depression 
      in bipolar disorder: harm avoidance influences medium-term treatment outcome.
PG  - 174-8
LID - 10.1159/000330364 [doi]
AB  - Comorbid conditions are frequent in bipolar disorder (BD) and may complicate the 
      treatment and course of illness. We investigated the role of substance use 
      disorder (SUD), axis II personality disorders (PD) and continuous personality 
      traits on the medium-term outcome (6 months) of treatment for bipolar depression. 
      One hundred and thirty-nine BD patients meeting criteria for a depressive episode 
      were included in the study. SUD and PD were diagnosed according to structured 
      interviews. Personality dimensions were evaluated by the Temperament and 
      Character Inventory. Depressive severity over time was evaluated by the Hamilton 
      Rating Scale for Depression. Neither PD nor SUD influenced the outcome of 
      depression. Variables independently associated with a poor outcome were a high 
      baseline severity and high scores for the temperamental trait of Harm Avoidance. 
      Though several limitations characterize the present study, neurotic personality 
      traits seem to be associated with a slower recovery from depressive symptoms in 
      BD, independently from their initial severity.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Mandelli, Laura
AU  - Mandelli L
AD  - Department of Psychiatry, University of Bologna, Bologna, Italy. 
      laura.mandelli@unibo.it
FAU - Mazza, Marianna
AU  - Mazza M
FAU - Di Nicola, Marco
AU  - Di Nicola M
FAU - Zaninotto, Leonardo
AU  - Zaninotto L
FAU - Harnic, Desiree
AU  - Harnic D
FAU - Catalano, Valeria
AU  - Catalano V
FAU - Tedeschi, Daniela
AU  - Tedeschi D
FAU - Martinotti, Giovanni
AU  - Martinotti G
FAU - Bria, Pietro
AU  - Bria P
FAU - Janiri, Luigi
AU  - Janiri L
FAU - Serretti, Alessandro
AU  - Serretti A
LA  - eng
PT  - Journal Article
DEP - 20120302
PL  - Switzerland
TA  - Psychopathology
JT  - Psychopathology
JID - 8401537
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/therapeutic use
MH  - Bipolar Disorder/diagnosis/*epidemiology
MH  - Comorbidity
MH  - Depressive Disorder/diagnosis/*drug therapy/*epidemiology
MH  - Female
MH  - *Harm Reduction
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Personality
MH  - Substance-Related Disorders/diagnosis/*epidemiology
MH  - Treatment Outcome
EDAT- 2012/03/09 06:00
MHDA- 2012/08/11 06:00
CRDT- 2012/03/09 06:00
PHST- 2010/09/06 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/08/11 06:00 [medline]
AID - 000330364 [pii]
AID - 10.1159/000330364 [doi]
PST - ppublish
SO  - Psychopathology. 2012;45(3):174-8. doi: 10.1159/000330364. Epub 2012 Mar 2.