PMID- 22398948
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20171116
IS  - 1423-0151 (Electronic)
IS  - 1011-7571 (Linking)
VI  - 21
IP  - 5
DP  - 2012
TI  - Increased risk of unfavorable metabolic outcome during short-term follow-up in 
      subjects with nonfunctioning adrenal adenomas.
PG  - 429-34
LID - 10.1159/000336589 [doi]
AB  - OBJECTIVE: To demonstrate long-term changes in the prevalence of several types of 
      metabolic derangements in subjects with nonfunctioning adrenal adenomas. SUBJECTS 
      AND METHODS: 273 subjects with adrenal adenomas, including 231 with 
      nonfunctioning adenoma and 42 with subclinical Cushing's syndrome (sCS), were 
      evaluated with respect to anthropometric and laboratory characteristics and 
      prevalence of type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, 
      metabolic syndrome (MS), prediabetes and cardiovascular disease (CVD). Median 
      duration was 24 months. Follow-up data of 114 participants with nonfunctioning 
      adrenal adenomas are also presented while those of 117 were missing. Follow-up 
      data regarding changes in anthropometric and laboratory parameters and prevalence 
      rates of metabolic disturbances were obtained from the medical records. RESULTS: 
      The prevalence rates for both patients with nonfunctioning adenoma and sCS were: 
      dyslipidemia: 161 (59%), hypertension: 147 (54%), MS: 128 (47%), prediabetes: 62 
      (23%), T2DM: 49 (18%), and CVD: 21 (8%). Hypertension and CVD were prevalent in 
      subjects with sCS compared to participants with nonfunctioning adenoma. In 
      follow-up, body mass index (p = 0.005), systolic blood pressure (p < 0.001), 
      waist circumference (p = 0.005), homeostasis model assessment (p = 0.046), 
      high-sensitivity C-reactive protein (p = 0.023), total cholesterol (p < 0.001) 
      and low-density lipoprotein cholesterol (p < 0.001) and prevalence of 
      hypertension (p < 0.001), dyslipidemia (p < 0.001), prediabetes (p < 0.001) and 
      MS (p < 0.01) significantly increased in subjects with nonfunctioning adenoma. 
      CONCLUSION: The data showed that nonfunctioning adrenal adenomas were associated 
      with the development or deterioration of atherosclerotic risk factors. Therefore, 
      follow-up and management strategies should be developed to decrease 
      atherosclerotic morbidity in those individuals.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Yener, S
AU  - Yener S
AD  - Division of Endocrinology and Metabolism, School of Medicine, Dokuz Eylul 
      University, Izmir, Turkey.
FAU - Ertilav, S
AU  - Ertilav S
FAU - Secil, M
AU  - Secil M
FAU - Akinci, B
AU  - Akinci B
FAU - Demir, T
AU  - Demir T
FAU - Kebapcilar, L
AU  - Kebapcilar L
FAU - Yesil, S
AU  - Yesil S
LA  - eng
PT  - Journal Article
DEP - 20120302
PL  - Switzerland
TA  - Med Princ Pract
JT  - Medical principles and practice : international journal of the Kuwait University, 
      Health Science Centre
JID - 8901334
RN  - 0 (Lipids)
SB  - IM
MH  - Adenoma/*epidemiology/metabolism
MH  - Adrenal Gland Neoplasms/*epidemiology/metabolism
MH  - Adult
MH  - Aged
MH  - Blood Pressure
MH  - Body Weights and Measures
MH  - Cardiovascular Diseases/*epidemiology/metabolism
MH  - Diabetes Mellitus, Type 2/*epidemiology/metabolism
MH  - Humans
MH  - Lipids/blood
MH  - Metabolic Syndrome/*epidemiology/metabolism
MH  - Middle Aged
MH  - Pituitary ACTH Hypersecretion/epidemiology/metabolism
MH  - Prevalence
EDAT- 2012/03/09 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/03/09 06:00
PHST- 2011/04/10 00:00 [received]
PHST- 2012/01/04 00:00 [accepted]
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
AID - 000336589 [pii]
AID - 10.1159/000336589 [doi]
PST - ppublish
SO  - Med Princ Pract. 2012;21(5):429-34. doi: 10.1159/000336589. Epub 2012 Mar 2.