PMID- 22399091
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120824
LR  - 20211021
IS  - 2162-3279 (Electronic)
IS  - 2162-3279 (Print)
VI  - 1
IP  - 2
DP  - 2011 Nov
TI  - Genetic association of the Phosphoinositide-3 kinase in schizophrenia and bipolar 
      disorder and interaction with a BDNF gene polymorphism.
PG  - 119-24
LID - 10.1002/brb3.23 [doi]
AB  - Phosphoinositide-3-kinase, class III (PIK3C3) is a member of the 
      phosphoinosite-3-kinases family, involved in cell signaling, membrane 
      trafficking, and neurodevelopment. Previous studies have indeed shown an 
      association between PIK3C3 gene variants and both bipolar disorder (BD) and 
      schizophrenia (SZ). Brain-derived neurotrophic factor (BDNF) is a 
      neurodevelopmental factor, which can regulate the PI3K signaling pathway. 
      Associations have been reported between BDNF gene polymorphisms and affective and 
      psychotic disorders. The aim of the present study was to replicate an association 
      between PIK3C3 and BDNF gene variants in SZ and BD and a putative epistasis 
      between the two genes. Patients meeting the DSM-IV criteria of BD and SZ were 
      included in this study (98 BD and 79 SZ) as well as 158 healthy controls. Blood 
      DNA was extracted and genotyping was performed either by the polymerase chain 
      reaction (PCR) technique followed by enzymatic digestion or by the 
      high-resolution melt (HRM) method. Genotype and haplotype association was 
      assessed with the UNPHASED statistical program.The results showed one nominal 
      association with BD (P < 0.02) and two risk haplotypes in both SZ (P < 0.001) and 
      BP (P < 0.0005), which survived multiple testing correction. A modest interaction 
      between a BDNF variant and PI3KC3 polymorphism was observed (P < 0.04).These 
      preliminary results confirm the genetic association of PI3K gene variants with 
      both SZ and BD, and support the hypothesis that SZ and BD share a genetic 
      background.
FAU - Carrard, Anthony
AU  - Carrard A
FAU - Salzmann, Annick
AU  - Salzmann A
FAU - Perroud, Nader
AU  - Perroud N
FAU - Gafner, Jeremie
AU  - Gafner J
FAU - Malafosse, Alain
AU  - Malafosse A
FAU - Karege, Felicien
AU  - Karege F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
PMC - PMC3236546
EDAT- 2012/03/09 06:00
MHDA- 2012/03/09 06:01
PMCR- 2011/11/01
CRDT- 2012/03/09 06:00
PHST- 2011/05/24 00:00 [received]
PHST- 2011/08/08 00:00 [revised]
PHST- 2011/09/10 00:00 [accepted]
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/03/09 06:01 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 10.1002/brb3.23 [doi]
PST - ppublish
SO  - Brain Behav. 2011 Nov;1(2):119-24. doi: 10.1002/brb3.23.