PMID- 22399237
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20120404
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 44
IP  - 4
DP  - 2012 Apr
TI  - Differential adipose tissue inflammatory state in obese nondiabetic Zucker fatty 
      rats compared to obese diabetic zucker diabetic fatty rats.
PG  - 273-8
LID - 10.1055/s-0032-1304581 [doi]
AB  - Adipose tissue (AT) inflammation is linked to the pathogenesis of diabetes in 
      obesity. Here, we compare the AT inflammatory state of 2 animal models of obesity 
      and obesity plus diabetes, respectively. Obese nondiabetic ZF rats exhibited a 
      trend towards increased proportions of CD11b positive cells in the adipose tissue 
      stroma vascular fraction suggesting a state of increased AT inflammation compared 
      to their lean littermates, but no alterations in systemic inflammatory 
      parameters. In contrast, obese diabetic ZDF rats exhibited systemic as well as 
      local AT inflammation with elevated levels of circulating Regulated upon 
      Activation, Normal T-cell Expressed and Secreted Protein (Rantes), interleukin 1beta 
      (IL-1beta) and monocyte chemotactic protein 1 (MCP-1), and an increased infiltration 
      of adipose tissue CD11b positive cells. Our data provide a novel phenotypic 
      characterisation of 2 common metabolic animal models and suggest an association 
      of obesity with local inflammation in adipose tissue, and an association of 
      diabetes with local inflammation in adipose tissue plus systemic inflammation. AT 
      inflammation in obesity might therefore initiate a process that above a certain 
      limits finally results in systemic inflammation and diabetes.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Miranville, A
AU  - Miranville A
AD  - Research and Development, Diabetes Division, Sanofi-Aventis Deutschland GmbH, 
      Frankfurt/M, Germany.
FAU - Herling, A W
AU  - Herling AW
FAU - Biemer-Daub, G
AU  - Biemer-Daub G
FAU - Voss, M D
AU  - Voss MD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120307
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adipose Tissue/*immunology/metabolism
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Cytokines/immunology
MH  - Diabetes Mellitus, Type 2/*immunology/metabolism
MH  - Humans
MH  - Male
MH  - Obesity/*immunology/metabolism
MH  - Rats
MH  - Rats, Zucker
EDAT- 2012/03/09 06:00
MHDA- 2012/08/28 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - 10.1055/s-0032-1304581 [doi]
PST - ppublish
SO  - Horm Metab Res. 2012 Apr;44(4):273-8. doi: 10.1055/s-0032-1304581. Epub 2012 Mar 
      7.