PMID- 22399409 OWN - NLM STAT- MEDLINE DCOM- 20120411 LR - 20161109 IS - 0065-2598 (Print) IS - 0065-2598 (Linking) VI - 739 DP - 2012 TI - The neural basis of semantic and episodic forms of self-knowledge: insights from functional neuroimaging. PG - 276-90 LID - 10.1007/978-1-4614-1704-0_18 [doi] AB - Throughout evolution, hominids have developed greater capacity to think about themselves in abstract and symbolic ways. This process has reached its apex in humans with the construction of a concept of self as a distinct entity with a personal history. This chapter provides a review of recent functional neuroimaging studies that have investigated the neural correlates of such "higher-level" aspects of the human self, focusing in particular on processes that allow individuals to consciously represent and reflect on their own personal attributes (semantic forms of self-knowledge) and experiences (episodic forms of self-knowledge). These studies point to the medial prefrontal cortex (MPFC) as a key neural structure for processing various kinds of self-referential information. We speculate that the MPFC may mediate dynamic processes that appraise and code the self-relatedness or self-relevance of information. This brain region may thus play a key role in creating the mental model of the self that is displayed in our mind at a given moment. FAU - D'Argembeau, Arnaud AU - D'Argembeau A AD - Department of Cognitive Sciences, Unversity of Liege, Liege, Belgium. a.dargembeau@ulg.ac.be FAU - Salmon, Eric AU - Salmon E LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Adv Exp Med Biol JT - Advances in experimental medicine and biology JID - 0121103 SB - IM MH - Awareness/*physiology MH - Brain/*physiology MH - *Ego MH - Functional Neuroimaging/*methods MH - Humans MH - *Semantics EDAT- 2012/03/09 06:00 MHDA- 2012/04/12 06:00 CRDT- 2012/03/09 06:00 PHST- 2012/03/09 06:00 [entrez] PHST- 2012/03/09 06:00 [pubmed] PHST- 2012/04/12 06:00 [medline] AID - 10.1007/978-1-4614-1704-0_18 [doi] PST - ppublish SO - Adv Exp Med Biol. 2012;739:276-90. doi: 10.1007/978-1-4614-1704-0_18.