PMID- 22399974
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120917
LR  - 20211021
IS  - 1424-8220 (Print)
IS  - 1424-8220 (Electronic)
IS  - 1424-8220 (Linking)
VI  - 9
IP  - 9
DP  - 2009
TI  - Dendritic cells as danger-recognizing biosensors.
PG  - 6730-51
LID - s90906730 [pii]
LID - 10.3390/s90906730 [doi]
AB  - Dendritic cells (DCs) are antigen presenting cells that are characterized by a 
      potent capacity to initiate immune responses. DCs comprise several subsets with 
      distinct phenotypes. After sensing any danger(s) to the host via their innate 
      immune receptors such as Toll-like receptors, DCs become mature and subsequently 
      present antigens to CD4(+) T cells. Since DCs possess the intrinsic capacity to 
      polarize CD4(+) helper cells, it is critical to understand the immunological 
      roles of DCs for clinical applications. Here, we review the different DC subsets, 
      their danger-sensing receptors and immunological functions. Furthermore, the 
      cytokine reporter mouse model for studying DC activation is introduced.
FAU - Gi, Mia
AU  - Gi M
AD  - Department of Bioscience and Biotechnology, College of Life Science, Sejong 
      University, Seoul, 143-747, Korea; E-Mails: gimia@sejong.ac.kr (M.G.); 
      spon13@naver.com (W.I.).
FAU - Im, Wooseok
AU  - Im W
FAU - Hong, Seokmann
AU  - Hong S
LA  - eng
PT  - Journal Article
DEP - 20090827
PL  - Switzerland
TA  - Sensors (Basel)
JT  - Sensors (Basel, Switzerland)
JID - 101204366
PMC - PMC3290479
OTO - NOTNLM
OT  - Interleukin 12
OT  - cytokine reporter mouse model
OT  - dendritic cells
OT  - pathogen-associated molecular patterns
OT  - toll-like receptors
EDAT- 2009/01/01 00:00
MHDA- 2009/01/01 00:01
PMCR- 2009/01/01
CRDT- 2012/03/09 06:00
PHST- 2009/07/02 00:00 [received]
PHST- 2009/08/19 00:00 [revised]
PHST- 2009/08/24 00:00 [accepted]
PHST- 2012/03/09 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2009/01/01 00:01 [medline]
PHST- 2009/01/01 00:00 [pmc-release]
AID - s90906730 [pii]
AID - sensors-09-06730 [pii]
AID - 10.3390/s90906730 [doi]
PST - ppublish
SO  - Sensors (Basel). 2009;9(9):6730-51. doi: 10.3390/s90906730. Epub 2009 Aug 27.