PMID- 22400365 OWN - NLM STAT- MEDLINE DCOM- 20120424 LR - 20191210 IS - 1660-9379 (Print) IS - 1660-9379 (Linking) VI - 7 IP - 318 DP - 2011 Nov 23 TI - [Tuberculosis and HIV co-infection: a therapeutic challenge]. PG - 2295-6, 2298-300 AB - Tuberculosis (TB) is the most frequent opportunistic infection in patients infected by the Human immunodeficiency virus (HIV). The mortality related to this co-infection can be reduced by the early introduction of an antiretroviral treatment. However, when treating subjects with TB and HIV, interactions between antiretroviral and tuberculostatic treatments can be problematic; also, these patients may develop, under treatment, an immune reconstitution inflammatory syndrome (IRIS). This review aims to summarize the necessary therapeutic adjustments which should be performed when treating patients co-infected with TB and HIV, the most important interactions between HIV and TB treatments, and the medical management of the IRIS. FAU - Charbonnier, Florian AU - Charbonnier F AD - Service de pneumologie, Departement des specialites de medecine, HUG, 1211 Geneve 14. florian.charbonnier@hcuge.ch FAU - Calmy, Alexandra AU - Calmy A FAU - Janssens, Jean-Paul AU - Janssens JP LA - fre PT - Evaluation Study PT - Journal Article PT - Review TT - Co-infection tuberculose et VIH: enjeux therapeutiques. PL - Switzerland TA - Rev Med Suisse JT - Revue medicale suisse JID - 101219148 RN - 0 (Antitubercular Agents) SB - IM MH - AIDS-Related Opportunistic Infections/drug therapy MH - Antiretroviral Therapy, Highly Active/adverse effects MH - Antitubercular Agents/adverse effects/therapeutic use MH - Choice Behavior MH - Coinfection/*drug therapy MH - HIV Infections/*complications/*drug therapy MH - Humans MH - Immune Reconstitution Inflammatory Syndrome/chemically induced MH - Models, Biological MH - Tuberculosis/*complications/*drug therapy EDAT- 2012/03/10 06:00 MHDA- 2012/04/25 06:00 CRDT- 2012/03/10 06:00 PHST- 2012/03/10 06:00 [entrez] PHST- 2012/03/10 06:00 [pubmed] PHST- 2012/04/25 06:00 [medline] PST - ppublish SO - Rev Med Suisse. 2011 Nov 23;7(318):2295-6, 2298-300.