PMID- 22400904
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20161125
IS  - 1093-5266 (Print)
IS  - 1093-5266 (Linking)
VI  - 15
IP  - 4
DP  - 2012 Jul-Aug
TI  - Extranodal rosai-dorfman disease presenting as a solitary mass with human 
      herpesvirus 6 detection in a pediatric patient.
PG  - 324-8
LID - 10.2350/11-11-1110-CR.1 [doi]
AB  - In Rosai-Dorfman disease (RDD), exclusive extranodal involvement with lesions 
      limited to the kidneys is very uncommon and has been described only in adult 
      patients. Occasionally, human herpesvirus 6 (HHV-6) has also been detected in RDD 
      tissue samples. We present the case of a 7-year-old boy referred to our center 
      presenting a single solid mass in the right kidney measuring 3.4 cm, detected 
      both on contrast computed tomography and magnetic resonance imaging. Surgical 
      excision was successfully completed, and the pathology report informed 
      characteristic histopathology and immmunohistochemistry features of RDD. Human 
      herpesvirus 6 was detected and amplified by polymerase chain reaction, as well as 
      by immunohistochemistry. We discuss imaging and histology-based differential 
      diagnoses in the pediatric age group. Although RDD is a rare histiocytic disorder 
      of unknown etiology and pathogenesis, the presence of HHV-6 observed in this case 
      supports the possibility of an abnormal immunologic response linked to viral 
      presence.
FAU - Arakaki, Naomi
AU  - Arakaki N
AD  - Department of Neuropathology, FLENI, Montaneses 2325, 3rd Floor, Buenos Aires, 
      Argentina, 1428.
FAU - Gallo, Guillermo
AU  - Gallo G
FAU - Majluf, Rodolfo
AU  - Majluf R
FAU - Diez, Blanca
AU  - Diez B
FAU - Arias, Eugenia
AU  - Arias E
FAU - Riudavets, Miguel A
AU  - Riudavets MA
FAU - Sevlever, Gustavo
AU  - Sevlever G
LA  - eng
PT  - Journal Article
DEP - 20120308
PL  - United States
TA  - Pediatr Dev Pathol
JT  - Pediatric and developmental pathology : the official journal of the Society for 
      Pediatric Pathology and the Paediatric Pathology Society
JID - 9809673
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Child
MH  - DNA, Viral/analysis
MH  - Diagnosis, Differential
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Histiocytosis, Sinus/*diagnosis/surgery/virology
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney/diagnostic imaging/pathology
MH  - Kidney Diseases/*diagnosis/surgery/virology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/*diagnosis/surgery/virology
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2012/03/10 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/03/10 06:00
PHST- 2012/03/10 06:00 [entrez]
PHST- 2012/03/10 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.2350/11-11-1110-CR.1 [doi]
PST - ppublish
SO  - Pediatr Dev Pathol. 2012 Jul-Aug;15(4):324-8. doi: 10.2350/11-11-1110-CR.1. Epub 
      2012 Mar 8.