PMID- 22402332
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20151119
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 46
IP  - 2
DP  - 2012 May
TI  - c-Jun-dependent sulfiredoxin induction mediates BDNF protection against 
      mitochondrial inhibition in rat cortical neurons.
PG  - 450-62
LID - 10.1016/j.nbd.2012.02.010 [doi]
AB  - In current study, we tested the hypothesis that c-Jun-dependent sulfiredoxin 
      expression mediates protective effects of brain-derived neurotrophic factor 
      (BDNF) against neurotoxicity induced by 3-nitropropionic acid (3-NP), a 
      mitochondrial complex II inhibitor, in primary rat cortical cultures. We found 
      that BDNF-dependent c-Jun expression and nuclear translocation required prior 
      phosphorylation of extracellular signal-regulated kinase (ERK)1/2, but not Akt. 
      BDNF also transiently activated the expression of sulfiredoxin, an ATP-dependent 
      antioxidant enzyme, at both mRNA and protein levels. Furthermore, both c-Jun 
      siRNA and ERK1/2 inhibitor PD98059 suppressed BDNF-induced sulfiredoxin 
      expression. Finally, PD98059, c-Jun siRNA, and sulfiredoxin siRNA all abrogated 
      BDNF-mediated 3-NP resistance. Together, these results established a signaling 
      cascade of "BDNF --> ERK1/2-Pi --> c-Jun --> sulfiredoxin --> 3-NP resistance". We 
      therefore conclude that c-Jun-induced sulfiredoxin mediates the BDNF-dependent 
      neuroprotective effects against 3-NP toxicity in primary rat cortical neurons, at 
      least in part.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Wu, Chia-Lin
AU  - Wu CL
AD  - Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, 
      Taipei, Taiwan.
FAU - Yin, Jiu-Haw
AU  - Yin JH
FAU - Hwang, Chi-Shin
AU  - Hwang CS
FAU - Chen, Shang-Der
AU  - Chen SD
FAU - Yang, Ding-Yah
AU  - Yang DY
FAU - Yang, Ding-I
AU  - Yang DI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120303
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Nitro Compounds)
RN  - 0 (Propionates)
RN  - EC 1.8.- (Oxidoreductases Acting on Sulfur Group Donors)
RN  - EC 1.8.- (Srxn1 protein, rat)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - QY4L0FOX0D (3-nitropropionic acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology/drug effects/enzymology
MH  - Enzyme Induction/physiology
MH  - JNK Mitogen-Activated Protein Kinases/*physiology
MH  - Mitochondria/*enzymology
MH  - Neural Inhibition/drug effects/*physiology
MH  - Neurons/drug effects/*enzymology
MH  - Neuroprotective Agents/pharmacology
MH  - Nitro Compounds/antagonists & inhibitors/toxicity
MH  - Oxidoreductases Acting on Sulfur Group Donors/*biosynthesis/physiology
MH  - Propionates/antagonists & inhibitors/toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/03/10 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/03/10 06:00
PHST- 2011/10/28 00:00 [received]
PHST- 2012/01/20 00:00 [revised]
PHST- 2012/02/20 00:00 [accepted]
PHST- 2012/03/10 06:00 [entrez]
PHST- 2012/03/10 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - S0969-9961(12)00065-4 [pii]
AID - 10.1016/j.nbd.2012.02.010 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2012 May;46(2):450-62. doi: 10.1016/j.nbd.2012.02.010. Epub 2012 
      Mar 3.