PMID- 22402899
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20211021
IS  - 1433-0458 (Electronic)
IS  - 0017-6192 (Linking)
VI  - 60
IP  - 3
DP  - 2012 Mar
TI  - [Diagnosis and therapy of atypical reflux symptoms when PPI therapy fails].
PG  - 193-9
LID - 10.1007/s00106-011-2430-9 [doi]
AB  - Gastroesophageal reflux disease (GERD) is a frequent chronic disorder occurring 
      in two forms: on the one hand, typical symptoms such as heartburn and acid 
      regurgitation are seen, while on the other hand atypical (extraesophageal) 
      symptoms such as chronic cough, hoarseness, recurrent sinusitis, globus 
      sensations in the throat, a burning feeling on the tongue, dental erosions and 
      the constant need to clear the throat can be associated with gastroesophageal 
      reflux. The standard therapeutic medical procedure comprises the administration 
      of acid-suppressive agents, proton pump inhibitors (PPI). However, this therapy 
      has proved to be ineffective in a number of patients, especially in atypical 
      GERD. Only after reliable identification of the GERD patient by using valid 
      diagnostic tools medical or interventional therapeutic options can be applied 
      individually. In the absence of atypical GERD symptoms, the diagnosis of GERD 
      becomes very unlikely and other causes of the symptoms need to be taken into 
      consideration.
FAU - Bajbouj, M
AU  - Bajbouj M
AD  - II. Medizinische Klinik, Klinikum rechts der Isar, TU Munchen, Ismaningerstr. 22, 
      81575, Munchen, Deutschland. monther.bajbouj@lrz.tum.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Diagnostik und Therapie atypischer Refluxsymptome bei fehlendem PPI-Ansprechen.
PL  - Germany
TA  - HNO
JT  - HNO
JID - 2985099R
RN  - 0 (GABA Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - GABA Antagonists/*therapeutic use
MH  - Gastroesophageal Reflux/*diagnosis/*therapy
MH  - Humans
MH  - Laryngopharyngeal Reflux/*diagnosis/*therapy
MH  - Otorhinolaryngologic Surgical Procedures/*methods
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Treatment Failure
MH  - Treatment Outcome
EDAT- 2012/03/10 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/03/10 06:00
PHST- 2012/03/10 06:00 [entrez]
PHST- 2012/03/10 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 10.1007/s00106-011-2430-9 [doi]
PST - ppublish
SO  - HNO. 2012 Mar;60(3):193-9. doi: 10.1007/s00106-011-2430-9.