PMID- 22404136
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20131121
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 4
IP  - 4
DP  - 2012 Apr
TI  - Preparation and antimicrobial properties of gemini surfactant-supported triiodide 
      complex system.
PG  - 2116-23
LID - 10.1021/am300094f [doi]
AB  - Iodine is an effective, simple, and inexpensive bactericide in disinfection. 
      However, the poor solubility and stability of iodine in water limit its 
      applications. In addition, the active iodine content in the commercial iodophors 
      is quite low, and the reported triiodide complex is unstable. In this work, a 
      long-term stable triiodide complex antimicrobial system was prepared by mixing 
      iodine and a cationic gemini surfactant into lauryldimethylamine oxide (LDAO) 
      aqueous solution, and its stability was examined by means of UV-vis 
      spectrophotometry. It was found that the content of LDAO, cationic gemini 
      surfactant and H(2)SO(4) played crucial roles in stabilizing antimicrobial 
      system, and the active iodine (i.e., triiodide complex) content of the optimum 
      formulation can remain stable for 150 days, as iodine is encapsulated by the 
      mixed vesicles assembled by the protonated LDAO and the added gemini surfactant. 
      However, the active iodine reduced rapidly when NaCl was added or the pH was 
      increased in the environment. Furthermore, the antimicrobial efficacy of the 
      optimized formulation was studied against Candida albicans, and more than 4 log 
      reduction in viable cell after 5 min of contact was obtained.
FAU - He, Shuai
AU  - He S
AD  - Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 
      People's Republic of China.
FAU - Wang, Biqing
AU  - Wang B
FAU - Chen, Honglin
AU  - Chen H
FAU - Tang, Chongli
AU  - Tang C
FAU - Feng, Yujun
AU  - Feng Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120321
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Antifungal Agents)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0 (Surface-Active Agents)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - Antifungal Agents/*chemistry/pharmacology
MH  - Candida albicans/drug effects/growth & development
MH  - Drug Stability
MH  - Hydrogen-Ion Concentration
MH  - Iodine/chemistry/*pharmacology
MH  - Quaternary Ammonium Compounds/*chemistry/pharmacology
MH  - Surface-Active Agents/*chemistry/pharmacology
EDAT- 2012/03/13 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/03/13 06:00
PHST- 2012/03/13 06:00 [entrez]
PHST- 2012/03/13 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 10.1021/am300094f [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2012 Apr;4(4):2116-23. doi: 10.1021/am300094f. Epub 
      2012 Mar 21.