PMID- 22404535
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20161020
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Linking)
VI  - 26
IP  - 2
DP  - 2013 Feb-Mar
TI  - Effect of acid-suppressive therapy on narrow band imaging findings in 
      gastroesophageal reflux disease: a pilot study.
PG  - 124-9
LID - 10.1111/j.1442-2050.2012.01335.x [doi]
AB  - Standard endoscopy is an insensitive test for gastroesophageal reflux disease 
      (GERD). Narrow band imaging (NBI) endoscopy enhances visualization of the distal 
      esophagus. NBI patterns like intrapapillary capillary loop (IPCL) dilatation, 
      tortuosity, and increased number; microerosions; increased vascularity at the 
      squamocolumnar junction (SCJ); ridge-villous pattern below the SCJ; and presence 
      of columnar islands in the distal esophagus have been suggested as features of 
      GERD. We evaluated the effect of proton pump inhibitor (PPI) therapy on NBI 
      findings in GERD patients. Patients prospectively underwent NBI upper endoscopy 
      before and after PPI therapy. NBI findings were recorded at each endoscopy. 
      Twenty-one patients with GERD symptoms (mean age 60.0 years; males 90.5%; white 
      90.5%) were studied. After PPI therapy, there was a significant reduction in the 
      proportion of patients with the following NBI features: IPCL tortuosity (90% vs. 
      4.8%, P < 0.0001), dilated IPCLs (86% vs. 9.5%, P < 0.0001), and increased 
      vascularity at the SCJ (43% vs. 9.5%, P= 0.0082). PPI led to healing of all 
      microerosions (71% vs. 0%, P < 0.0001) and disappearance of ridge-villous 
      patterns below the SCJ (14% vs. 0%, P < 0.0001). There was no significant change 
      in the proportion of patients with increased numbers of IPCLs pre- and post-PPI 
      therapy (71% vs. 48%, P= 0.09) or columnar islands in the distal esophagus (38% 
      vs. 29%, P= 0.31). In patients with GERD symptoms, NBI features suggestive of 
      GERD respond to PPI; suggesting these features are truly acid-mediated. These 
      findings need to be confirmed by randomized controlled trials.
CI  - Published 2012. This article is a U.S. Government work and is in the public 
      domain in the USA.
FAU - Lynch, C R
AU  - Lynch CR
AD  - Division of Gastroenterology and Hepatology, Department Veterans Affairs Medical 
      Center, University of Kansas School of Medicine, Kansas City, Missouri 
      64128-2295, USA.
FAU - Wani, S
AU  - Wani S
FAU - Rastogi, A
AU  - Rastogi A
FAU - Keighley, J
AU  - Keighley J
FAU - Mathur, S
AU  - Mathur S
FAU - Higbee, A
AU  - Higbee A
FAU - Bansal, A
AU  - Bansal A
FAU - Gaddam, S
AU  - Gaddam S
FAU - Sharma, P
AU  - Sharma P
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20120309
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (Proton Pump Inhibitors)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Drug Administration Schedule
MH  - Esomeprazole/*therapeutic use
MH  - Esophagoscopy/*methods
MH  - Esophagus/*pathology
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Narrow Band Imaging
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Single-Blind Method
MH  - Treatment Outcome
EDAT- 2012/03/13 06:00
MHDA- 2013/07/13 06:00
CRDT- 2012/03/13 06:00
PHST- 2012/03/13 06:00 [entrez]
PHST- 2012/03/13 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
AID - 10.1111/j.1442-2050.2012.01335.x [doi]
PST - ppublish
SO  - Dis Esophagus. 2013 Feb-Mar;26(2):124-9. doi: 10.1111/j.1442-2050.2012.01335.x. 
      Epub 2012 Mar 9.