PMID- 22404603
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20191112
IS  - 0001-723X (Print)
IS  - 0001-723X (Linking)
VI  - 56
IP  - 1
DP  - 2012
TI  - Mechanisms of suppression of interferon production by porcine reproductive and 
      respiratory syndrome virus.
PG  - 3-9
AB  - The recently emerged porcine reproductive and respiratory syndrome virus (PRRSV) 
      leads to one of the most economically significant infectious diseases of swine 
      worldwide. The virus modulates the host innate and adaptive immunity to escape 
      its immune response to facilitate the infection. Interferons (INFs) are principal 
      antiviral cytokines, which represent components of the innate immunity and are 
      regarded as a bridge between the innate and adaptive immunity. Currently, 
      accumulating evidence indicates that the virus has developed various strategies 
      to counteract the IFN production. Here, various mechanisms utilized by the virus 
      to antagonize the IFN induction are reviewed.
FAU - Zhu, L
AU  - Zhu L
AD  - Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
FAU - Zhou, Y
AU  - Zhou Y
FAU - Tong, G
AU  - Tong G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Slovakia
TA  - Acta Virol
JT  - Acta virologica
JID - 0370401
RN  - 0 (NF-kappa B)
RN  - 0 (Toll-Like Receptor 3)
RN  - 0 (Viral Nonstructural Proteins)
RN  - 77238-31-4 (Interferon-beta)
RN  - EC 3.6.4.13 (DEAD-box RNA Helicases)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - DEAD-box RNA Helicases/genetics/immunology
MH  - Gene Expression/*immunology
MH  - Host-Pathogen Interactions/*immunology
MH  - Immunity, Innate
MH  - Interferon-beta/genetics/immunology/*metabolism
MH  - Macrophages, Alveolar/*immunology/virology
MH  - NF-kappa B/genetics/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/genetics/immunology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Protein Binding
MH  - Signal Transduction/immunology
MH  - Swine
MH  - Toll-Like Receptor 3/genetics/immunology
MH  - Viral Nonstructural Proteins/genetics/metabolism
EDAT- 2012/03/13 06:00
MHDA- 2012/06/13 06:00
CRDT- 2012/03/13 06:00
PHST- 2012/03/13 06:00 [entrez]
PHST- 2012/03/13 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.4149/av_2012_01_3 [doi]
PST - ppublish
SO  - Acta Virol. 2012;56(1):3-9. doi: 10.4149/av_2012_01_3.