PMID- 22405894
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120402
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 514
IP  - 1
DP  - 2012 Apr 11
TI  - Differential plasticity of microglial cells in the rostrocaudal neuraxis of the 
      accessory olfactory bulb of female mice following mating and stud male exposure.
PG  - 116-21
LID - 10.1016/j.neulet.2012.02.071 [doi]
AB  - The formation of an olfactory recognition memory by female mice for the stud male 
      pheromones requires two fundamental conditions: incidence of mating and retention 
      of the stud male with the female for a critical 6h interval following mating. 
      This biologically critical recognition memory results from plasticity of 
      reciprocal dendrodendritic synapses in the accessory olfactory bulb (AOB). In 
      this study, a microglia marker antibody (ionized calcium-binding adaptor protein, 
      Iba1) was used to determine how mating and stud pheromones affect microglia in 
      the AOB rostrocaudal axis in female mice. The results showed that compared with 
      estrus and mating only, mating and pheromone exposure significantly increased 
      Iba1 immunoreactivity in the AOB evidenced by increased complexity of ramified 
      microglial processes characteristic of resting microglial morphological 
      phenotype, particularly in the rostral AOB. The density of Iba1 staining after 
      mating and stud pheromone exposure was higher in the rostral - compared to caudal 
      - AOB and was most prevalent in the external plexiform layer, the site of 
      reciprocal mitral-granule dendrodendritic synapses. While cells with activated 
      phenotype were observed in caudal AOB during estrus, mating/pheromone exposure 
      appeared to induce a morphological transformation to the resting microglia 
      phenotype. Since previous evidence implicate the rostral AOB in processing 
      pheromonal signals and microglial cells monitor active synapses, these 
      observations have important functional implications for a potential role for 
      microglia in processing pheromonal signals in the AOB during the formation of 
      olfactory memory.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Okere, Chuma O
AU  - Okere CO
AD  - Department of Biological Sciences, Clark Atlanta University, Atlanta, GA 30314, 
      USA. cokere@cau.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120303
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Aif1 protein, mouse)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Pheromones)
SB  - IM
MH  - Animals
MH  - Calcium-Binding Proteins/metabolism
MH  - Female
MH  - Male
MH  - Mice
MH  - Microfilament Proteins/metabolism
MH  - Microglia/*metabolism
MH  - Olfactory Bulb/*metabolism
MH  - Pheromones/*metabolism
MH  - Sexual Behavior, Animal/*physiology
MH  - Smell/*physiology
EDAT- 2012/03/13 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/03/13 06:00
PHST- 2011/10/13 00:00 [received]
PHST- 2012/01/20 00:00 [revised]
PHST- 2012/02/20 00:00 [accepted]
PHST- 2012/03/13 06:00 [entrez]
PHST- 2012/03/13 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - S0304-3940(12)00297-2 [pii]
AID - 10.1016/j.neulet.2012.02.071 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Apr 11;514(1):116-21. doi: 10.1016/j.neulet.2012.02.071. Epub 
      2012 Mar 3.