PMID- 22407468
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20180126
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 148
IP  - 3
DP  - 2012 Sep
TI  - In utero and lactational lanthanum exposure induces olfactory dysfunction 
      associated with downregulation of betaIII-tubulin and olfactory marker protein in 
      young rats.
PG  - 383-91
LID - 10.1007/s12011-012-9386-9 [doi]
AB  - We evaluated the role of betaIII-tubulin in the morphology of olfactory receptor 
      neuron (ORN) and olfactory dysfunction in offspring caused by prenatal and 
      postnatal lanthanum exposure. Pregnant rats were exposed to 0.25% lanthanum 
      chloride in drinking water from gestational day (GD) 7 until postnatal day 21. 
      From postnatal day 23 until postnatal day 28, pups were examined with buried food 
      pellet and olfactory maze test. The ultrastructural features of ORNs in the 
      olfactory epithelium (OE) were observed by transmission electron microscope. The 
      expression of betaIII-tubulin and olfactory marker protein (OMP) in the tissue 
      sections and homogenates of OE were, respectively, measured by immunodetection 
      and western blot. Behavioral analysis of olfaction showed that lanthanum chloride 
      exposure induced olfactory dysfunction. Offsprings exposed to lanthanum chloride 
      showed enlarged ORN knobs and a decreased number of cilia. In addition, the 
      levels of OMP and betaIII-tubulin expression in lanthanum chloride exposure 
      offsprings significantly decreased. Developmental lanthanum exposure could impair 
      olfaction, and this deficit may be attributed to the downregulation of 
      betaIII-tubulin and OMP in the OE.
FAU - Hao, Shuai
AU  - Hao S
AD  - Department of Otolaryngology, First Affiliated Hospital of China Medical 
      University, No. 155, Nanjing North Street, Heping District, Shenyang, Liaoning 
      110001, People's Republic of China.
FAU - Yu, Fei
AU  - Yu F
FAU - Yan, Aihui
AU  - Yan A
FAU - Zhang, Yang
AU  - Zhang Y
FAU - Han, Jiali
AU  - Han J
FAU - Jiang, Xuejun
AU  - Jiang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120310
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Olfactory Marker Protein)
RN  - 0 (Tubulin)
RN  - 04M8624OXV (lanthanum chloride)
RN  - 6I3K30563S (Lanthanum)
SB  - IM
MH  - Animals
MH  - Female
MH  - Immunohistochemistry
MH  - Lanthanum/*toxicity
MH  - Male
MH  - Microscopy, Electron, Transmission
MH  - Olfactory Marker Protein/metabolism
MH  - Olfactory Mucosa/metabolism
MH  - Olfactory Receptor Neurons/drug effects/metabolism
MH  - Pregnancy
MH  - Rats
MH  - Tubulin/*metabolism
EDAT- 2012/03/13 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/03/13 06:00
PHST- 2012/02/08 00:00 [received]
PHST- 2012/03/01 00:00 [accepted]
PHST- 2012/03/13 06:00 [entrez]
PHST- 2012/03/13 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1007/s12011-012-9386-9 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2012 Sep;148(3):383-91. doi: 10.1007/s12011-012-9386-9. Epub 
      2012 Mar 10.