PMID- 22410729
OWN - NLM
STAT- MEDLINE
DCOM- 20120712
LR  - 20120313
IS  - 1537-4505 (Electronic)
IS  - 1531-7129 (Linking)
VI  - 33
IP  - 3
DP  - 2012 Apr
TI  - Recovery from forward masking in elderly cochlear implant users.
PG  - 355-63
LID - 10.1097/MAO.0b013e318248ede5 [doi]
AB  - OBJECTIVE: To compare temporal aspects of peripheral neural responses and central 
      auditory perception between groups of younger adult and elderly cochlear implant 
      users. STUDY DESIGN: Cohort study. SETTING: Academic hospital and cochlear 
      implant center. PATIENTS: Adult cochlear implant users aged 28 to 57 years in the 
      younger group (n = 5) and 61 to 89 years (n = 9) in the elderly group. All 
      subjects used Advanced Bionics devices. INTERVENTION: Diagnostic. MAIN OUTCOME 
      MEASURES: Time constants of neural (i.e., electrically evoked compound action 
      potentials [ECAPs]) and perceptual recovery from forward masking. Interstimulus 
      intervals (ISIs) were varied in both experiments. RESULTS: ECAP recovery rates 
      were equivalent between groups, and no correlation was found between ECAP 
      recovery and age. No correlations were found between ECAP recovery and speech 
      perception. Psychophysical recovery was significantly slower in the elderly 
      compared with the younger subjects (p < 0.0005), with a significant effect of age 
      (R2 = 0.70, p < 0.0005). At the longest ISI (240 ms), elderly subjects 
      experienced a mean maximum threshold shift of 35.2% (relative to 1 ms ISI) versus 
      14.8% for younger subjects. There was a significant positive relationship between 
      psychophysical recovery and consonant-nucleus-consonant word scores (R2 = 0.62, p 
      < 0.001), although no relationship was found with Hearing in Noise Test 
      sentences. CONCLUSION: These findings suggest that difficulties observed in 
      speech perception by elderly CI users may be due to age-related changes in the 
      central rather than peripheral auditory system. With further study, these results 
      may provide information to allow clinicians to assess patients' temporal 
      processing abilities and facilitate setting program parameters that will maximize 
      their auditory perceptual experience with a cochlear implant.
FAU - Lee, Edward R
AU  - Lee ER
AD  - Department of Otolaryngology and Communication Sciences, Medical College of 
      Wisconsin, Milwaukee, Wisconsin 53226, USA.
FAU - Friedland, David R
AU  - Friedland DR
FAU - Runge, Christina L
AU  - Runge CL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Otol Neurotol
JT  - Otology & neurotology : official publication of the American Otological Society, 
      American Neurotology Society [and] European Academy of Otology and Neurotology
JID - 100961504
SB  - IM
MH  - Acoustic Stimulation
MH  - Action Potentials
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/physiology
MH  - Auditory Perception/*physiology
MH  - Auditory Threshold
MH  - Central Nervous System/physiopathology
MH  - *Cochlear Implants
MH  - Cohort Studies
MH  - Deafness/etiology/therapy
MH  - Female
MH  - Hearing Tests
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Perceptual Masking/*physiology
MH  - Peripheral Nervous System/physiopathology
MH  - Recovery of Function
MH  - Speech Discrimination Tests
MH  - Speech Perception/physiology
EDAT- 2012/03/14 06:00
MHDA- 2012/07/13 06:00
CRDT- 2012/03/14 06:00
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/07/13 06:00 [medline]
AID - 00129492-201204000-00012 [pii]
AID - 10.1097/MAO.0b013e318248ede5 [doi]
PST - ppublish
SO  - Otol Neurotol. 2012 Apr;33(3):355-63. doi: 10.1097/MAO.0b013e318248ede5.