PMID- 22411071
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20120424
IS  - 1896-494X (Electronic)
IS  - 1232-1087 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Jun
TI  - The effect of exposure route on the distribution and excretion of 
      hexachloronaphthalene in rats.
PG  - 185-95
LID - 10.2478/S13382-012-0021-y [doi]
AB  - OBJECTIVES: Polychlorinated naphthalenes (PCNs), like other persistent organic 
      pollutants (POPs), are widespread, global environmental contaminants. These 
      compounds still represent a great environmental problem, mostly because of the 
      risk of secondary air pollution. They are characterized by long durability and 
      tendency to bioaccumulate, which means that they are practically ubiquitous in 
      all environmental media and ecosystems. The aim of this study was to investigate 
      the distribution and excretion of hexachloronaphthalene (HxCN) in rats following 
      a single intraperitoneal or intragastrical administration. MATERIALS AND METHODS: 
      Experiments were performed on male outbred Wistar rats with body weight of 
      220-240 g. They were given [(14)C]-HxCN intraperitoneally (i.p.) or 
      intragastrically (p.o.) in a single dose of 0.3 mg (150 kBq) per rat. The 
      distribution of radioactivity in blood and selected organs or tissues, as well as 
      urine and faeces excretion were traced following the administration. RESULTS: The 
      decline of [(14)C]-HxCN in plasma was biphasic and the calculated half-lives for 
      phases I and II were ~6 and 350 h, respectively. Following 120 h after 
      administration, ~51% (intragastrical) and ~34% (intraperitoneal) of the dose were 
      excreted with faeces. Regardless of the administration route, the highest HxCN 
      concentrations were found in liver and adipose tissue, where the compound showed 
      high retention: the highest retention in liver was found 24 h after 
      intragastrical (32%) and intraperitoneal (38%) administration while in adipose 
      tissue ~30% retention was observed 120 h after HxCN administration regardless of 
      its route. CONCLUSIONS: Following the calculation of the balance of total 
      [(14)C]-HxCN excreted and stored, it was found that hexachloronaphthalene belongs 
      to the compounds of a slow turnover rate, and in the case of repeated exposure it 
      may accumulate in the rat body.
FAU - Kilanowicz, Anna
AU  - Kilanowicz A
AD  - Department of Toxicology, Faculty of Pharmacy, Medical University, Lodz, Poland. 
      anna.kilanowicz@umed.lodz.pl
FAU - Darago, Adam
AU  - Darago A
FAU - Skrzypinska-Gawrysiak, Malgorzata
AU  - Skrzypinska-Gawrysiak M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120311
PL  - Poland
TA  - Int J Occup Med Environ Health
JT  - International journal of occupational medicine and environmental health
JID - 9437093
RN  - 0 (Environmental Pollutants)
RN  - 0 (Naphthalenes)
RN  - 58877-88-6 (1,2,3,4,5,6-hexachloronaphthalene)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Drug Administration Routes
MH  - Environmental Exposure/*analysis
MH  - Environmental Monitoring/methods
MH  - Environmental Pollutants/administration & dosage/*pharmacokinetics
MH  - Feces/*chemistry
MH  - Injections, Intraperitoneal
MH  - Intubation, Gastrointestinal
MH  - Male
MH  - Naphthalenes/administration & dosage/*pharmacokinetics
MH  - Rats
MH  - Rats, Wistar
MH  - Stomach
MH  - Tissue Distribution
MH  - Urine/*chemistry
EDAT- 2012/03/14 06:00
MHDA- 2012/09/29 06:00
CRDT- 2012/03/14 06:00
PHST- 2011/11/25 00:00 [received]
PHST- 2012/01/16 00:00 [accepted]
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - 10.2478/S13382-012-0021-y [doi]
PST - ppublish
SO  - Int J Occup Med Environ Health. 2012 Jun;25(2):185-95. doi: 
      10.2478/S13382-012-0021-y. Epub 2012 Mar 11.