PMID- 22411281
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20211021
IS  - 1558-9102 (Electronic)
IS  - 1092-4388 (Print)
IS  - 1092-4388 (Linking)
VI  - 55
IP  - 6
DP  - 2012 Dec
TI  - Masked priming effects in aphasia: evidence of altered automatic spreading 
      activation.
PG  - 1613-25
LID - 10.1044/1092-4388(2012/10-0260) [doi]
AB  - PURPOSE: Previous research has suggested that impairments of automatic spreading 
      activation may underlie some aphasic language deficits. The current study further 
      investigated the status of automatic spreading activation in individuals with 
      aphasia as compared with typical adults. METHOD: Participants were 21 individuals 
      with aphasia (12 fluent, 9 nonfluent) and 31 typical adults. Reaction time data 
      were collected on a lexical decision task with masked repetition primes, assessed 
      at 11 different interstimulus intervals (ISIs). Masked primes were used to assess 
      automatic spreading activation without the confound of conscious processing. The 
      various ISIs were used to assess the time to onset and duration of priming 
      effects. RESULTS: The control group showed maximal priming in the 200-ms ISI 
      condition, with significant priming at a range of ISIs surrounding that peak. 
      Participants with both fluent and nonfluent aphasia showed maximal priming 
      effects in the 250-ms ISI condition and primed across a smaller range of ISIs 
      than did the control group. CONCLUSIONS: Results suggest that individuals with 
      aphasia have slowed automatic spreading activation and impaired maintenance of 
      activation over time, regardless of fluency classification. These findings have 
      implications for understanding aphasic language impairment and for development of 
      aphasia treatments designed to directly address automatic language processes.
FAU - Silkes, JoAnn P
AU  - Silkes JP
AD  - University of Washington, Seattle, WA, USA. jsilkes@uw.edu
FAU - Rogers, Margaret A
AU  - Rogers MA
LA  - eng
GR  - F31 DC008736/DC/NIDCD NIH HHS/United States
GR  - P30 DC004661/DC/NIDCD NIH HHS/United States
GR  - T32 DC000033/DC/NIDCD NIH HHS/United States
PT  - Journal Article
DEP - 20120312
PL  - United States
TA  - J Speech Lang Hear Res
JT  - Journal of speech, language, and hearing research : JSLHR
JID - 9705610
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anomia/physiopathology
MH  - Aphasia, Broca/*physiopathology
MH  - Aphasia, Wernicke/*physiopathology
MH  - Consciousness/physiology
MH  - Decision Making/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Perceptual Masking/*physiology
MH  - Reaction Time/physiology
MH  - Repetition Priming/*physiology
MH  - Semantics
MH  - Young Adult
PMC - PMC4598179
MID - NIHMS726612
EDAT- 2012/03/14 06:00
MHDA- 2013/06/14 06:00
PMCR- 2015/10/08
CRDT- 2012/03/14 06:00
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
PHST- 2015/10/08 00:00 [pmc-release]
AID - 1092-4388_2012_10-0260 [pii]
AID - 10.1044/1092-4388(2012/10-0260) [doi]
PST - ppublish
SO  - J Speech Lang Hear Res. 2012 Dec;55(6):1613-25. doi: 
      10.1044/1092-4388(2012/10-0260). Epub 2012 Mar 12.