PMID- 22412897
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 3
DP  - 2012
TI  - Socio-economic position and type 2 diabetes risk factors: patterns in UK children 
      of South Asian, black African-Caribbean and white European origin.
PG  - e32619
LID - 10.1371/journal.pone.0032619 [doi]
LID - e32619
AB  - BACKGROUND: Socio-economic position (SEP) and ethnicity influence type 2 diabetes 
      mellitus (T2DM) risk in adults. However, the influence of SEP on emerging T2DM 
      risks in different ethnic groups and the contribution of SEP to ethnic 
      differences in T2DM risk in young people have been little studied. We examined 
      the relationships between SEP and T2DM risk factors in UK children of South 
      Asian, black African-Caribbean and white European origin, using the official UK 
      National Statistics Socio-economic Classification (NS-SEC) and assessed the 
      extent to which NS-SEC explained ethnic differences in T2DM risk factors. METHODS 
      AND FINDINGS: Cross-sectional school-based study of 4,804 UK children aged 9-10 
      years, including anthropometry and fasting blood analytes (response rates 70%, 
      68% and 58% for schools, individuals and blood measurements). Assessment of SEP 
      was based on parental occupation defined using NS-SEC and ethnicity on parental 
      self-report. Associations between NS-SEC and adiposity, insulin resistance (IR) 
      and triglyceride differed between ethnic groups. In white Europeans, lower NS-SEC 
      status was related to higher ponderal index (PI), fat mass index, IR and 
      triglyceride (increases per NS-SEC decrement [95%CI] were 1.71% [0.75, 2.68], 
      4.32% [1.24, 7.48], 5.69% [2.01, 9.51] and 3.17% [0.96, 5.42], respectively). In 
      black African-Caribbeans, lower NS-SEC was associated with lower PI (-1.12%; 
      [-2.01, -0.21]), IR and triglyceride, while in South Asians there were no 
      consistent associations between NS-SEC and T2DM risk factors. Adjustment for 
      NS-SEC did not appear to explain ethnic differences in T2DM risk factors, which 
      were particularly marked in high NS-SEC groups. CONCLUSIONS: SEP is associated 
      with T2DM risk factors in children but patterns of association differ by ethnic 
      groups. Consequently, ethnic differences (which tend to be largest in affluent 
      socio-economic groups) are not explained by NS-SEC. This suggests that strategies 
      aimed at reducing social inequalities in T2DM risk are unlikely to reduce 
      emerging ethnic differences in T2DM risk.
FAU - Thomas, Claudia
AU  - Thomas C
AD  - Population Health Research Centre, Division of Population Health Sciences and 
      Education, St Georges, University of London, London, United Kingdom. 
      clthomas@sgul.ac.uk
FAU - Nightingale, Claire M
AU  - Nightingale CM
FAU - Donin, Angela S
AU  - Donin AS
FAU - Rudnicka, Alicja R
AU  - Rudnicka AR
FAU - Owen, Christopher G
AU  - Owen CG
FAU - Sattar, Naveed
AU  - Sattar N
FAU - Cook, Derek G
AU  - Cook DG
FAU - Whincup, Peter H
AU  - Whincup PH
LA  - eng
GR  - BHF_/British Heart Foundation/United Kingdom
GR  - DH_/Department of Health/United Kingdom
GR  - G0501295/MRC_/Medical Research Council/United Kingdom
GR  - 068362/Z/02/Z/WT_/Wellcome Trust/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - CSO_/Chief Scientist Office/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120307
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Asia/ethnology
MH  - Black People
MH  - Caribbean Region/ethnology
MH  - Child
MH  - Diabetes Mellitus, Type 2/*ethnology
MH  - Female
MH  - Humans
MH  - Male
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - United Kingdom/epidemiology
MH  - White People
PMC - PMC3296720
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/03/14 06:00
MHDA- 2012/08/03 06:00
PMCR- 2012/03/07
CRDT- 2012/03/14 06:00
PHST- 2011/06/20 00:00 [received]
PHST- 2012/02/02 00:00 [accepted]
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
PHST- 2012/03/07 00:00 [pmc-release]
AID - PONE-D-11-11213 [pii]
AID - 10.1371/journal.pone.0032619 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(3):e32619. doi: 10.1371/journal.pone.0032619. Epub 2012 Mar 7.