PMID- 22413883
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20131121
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 27
IP  - 7
DP  - 2012 Jul
TI  - Segmental changes in smooth muscle contraction as a predictive factor of the 
      response to high-dose proton pump inhibitor treatment in patients with functional 
      chest pain.
PG  - 1192-9
LID - 10.1111/j.1440-1746.2012.07110.x [doi]
AB  - BACKGROUND AND AIMS: High-dose proton pump inhibitor (PPI) treatment leads to 
      relatively little symptomatic improvement in patients with functional chest pain 
      (FCP). This study was to evaluate the use of smooth muscle segmental changes in 
      esophageal contraction as measured by topographical plots of high resolution 
      manometry (HRM) as predictive factors of the response to high-dose PPI treatment 
      in FCP patients. METHODS: Thirty patients diagnosed with FCP were treated with 
      rabeprazole 20 mg twice daily for 2 weeks and classified as positive and negative 
      responders based on symptom intensity score. HRM topographical plots were 
      analyzed for segment lengths, maximal wave amplitudes, and pressure volumes of 
      the proximal and distal smooth muscle segments. RESULTS: A positive response was 
      observed in 23.3% of the patients. While the pressure volume of the proximal 
      segment was significantly higher in the positive responders than the negative 
      responders (900.4 +/- 91.5 mm Hg/cm per s vs. 780.5 +/- 133.3 mm Hg/cm per s, P = 
      0.017), the pressure volume of the distal segment was significantly lower in the 
      positive responders (1914.0 +/- 159.8 mm Hg/cm per s vs. 2140.5 +/- 276.2 mm Hg/cm 
      per s, P = 0.014). A prominent shifting in pressure volume to the distal segment 
      was observed in the negative responders compared with the positive responders 
      (segmental ratio of pressure volume (SRPV): 2.9 +/- 0.5 vs. 2.1 +/- 0.1, P < 0.001), 
      and 2.39 was found to be the SRPV that best differentiated positive and negative 
      responders. CONCLUSIONS: A low SRPV was associated with a positive response to 
      high-dose PPI treatment in patients with FCP.
CI  - (c) 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell 
      Publishing Asia Pty Ltd.
FAU - Lee, Hyuk
AU  - Lee H
AD  - Department of Internal Medicine, Institute of Gastroenterology, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Park, Jun Chul
AU  - Park JC
FAU - Shin, Sung Kwan
AU  - Shin SK
FAU - Lee, Sang Kil
AU  - Lee SK
FAU - Lee, Yong Chan
AU  - Lee YC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 32828355LL (Rabeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/administration & 
      dosage/pharmacology/therapeutic use
MH  - Adult
MH  - Chest Pain/*drug therapy/etiology/physiopathology
MH  - Drug Administration Schedule
MH  - Esophageal pH Monitoring
MH  - Esophagus/*drug effects/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Manometry/methods
MH  - Middle Aged
MH  - Muscle Contraction/*drug effects
MH  - Muscle, Smooth/*drug effects/physiopathology
MH  - Prognosis
MH  - Proton Pump Inhibitors/administration & dosage/*pharmacology/therapeutic use
MH  - Rabeprazole
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2012/03/15 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/03/15 06:00
PHST- 2012/03/15 06:00 [entrez]
PHST- 2012/03/15 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.1111/j.1440-1746.2012.07110.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2012 Jul;27(7):1192-9. doi: 
      10.1111/j.1440-1746.2012.07110.x.