PMID- 22413919
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20220409
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 11
DP  - 2012 Mar 13
TI  - Association of serum adipocytokine levels with cardiac autonomic neuropathy in 
      type 2 diabetic patients.
PG  - 24
LID - 10.1186/1475-2840-11-24 [doi]
AB  - BACKGROUND: Cardiac autonomic neuropathy (CAN) is a common complication of 
      diabetes associated with poor prognosis. In addition, the autonomic imbalance is 
      associated with cardiovascular disease (CVD) in diabetes. It is thought that 
      adipocytokines contribute to the increased risk of vascular complications in 
      patients with type 2 diabetes mellitus (T2DM). However, literature data on the 
      association between CAN with adipocytokines such as leptin, tumor necrosis 
      factor-alpha (TNF-alpha), adiponectin in subjects with T2DM is limited.Therefore, 
      in the present study, we examined the relationship between fasting serum leptin, 
      TNF- alpha and adiponectin and CAN in Korean T2DM patients. METHODS: A total of 
      142 T2DM patients (94 males, 48 females) were recruited. CAN was assessed by the 
      five tests according to the Ewing's protocol and the time and frequency domain of 
      the heart rate variability (HRV) was evaluated. Serum TNF-alpha and adiponectin 
      levels were measured using enzyme-linked immunosorbent assay and serum leptin 
      levels were measured using radioimmunoassay. RESULTS: Although, the mean levels 
      of leptin, TNF-alpha and adiponectin were not significantly different between the 
      groups with and without CAN, the levels of leptin and adiponectin had a tendency 
      to increase as the score of CAN increased (p = 0.05, p = 0.036). Serum leptin 
      levels demonstrated a negative correlation with low frequency (LF) in the upright 
      position (p = 0.037). Regarding TNF-alpha, a significant negative correlation was 
      observed with SDNN and RMSSD in the upright position (p = 0.023, p = 0.019). 
      Adiponectin levels were not related to any HRV parameters. Multivariate logistic 
      regression analysis demonstrated that the odds of CAN increased with a longer 
      duration of diabetes (1.25, [1.07-1.47]) and higher homeostatic model of 
      assessment-insulin resistance (HOMA-IR) (5.47, [1.8-16.5]). The relative risks 
      for the presence of CAN were 14.1 and 51.6 for the adiponectin 2nd, 3rd tertiles 
      when compared with first tertile (p-value for trend = 0.022). CONCLUSIONS: In the 
      present study, the higher serum adiponectin levels and HOMA-IR were associated 
      with an increased risk for the presence of CAN. Also, the CAN score correlated 
      with the serum adiponectin. Serum adipocytokines such as leptin and TNF-alpha 
      were significantly correlated with parameters of HRV, representative markers of 
      CAN. Future prospective studies with larger number of patients are required to 
      establish a direct relationship between plasma adipocytokine concentrations and 
      the development or severity of CAN.
FAU - Jung, Chan-Hee
AU  - Jung CH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Soonchunhyang University School of Medicine, #108 Jung-Dong, Bucheon, 110-746 
      Kyunggi-Do, Korea.
FAU - Kim, Bo-Yeon
AU  - Kim BY
FAU - Kim, Chul-Hee
AU  - Kim CH
FAU - Kang, Sung-Koo
AU  - Kang SK
FAU - Jung, Sang-Hee
AU  - Jung SH
FAU - Mok, Ji-Oh
AU  - Mok JO
LA  - eng
PT  - Journal Article
DEP - 20120313
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Leptin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adipokines/*blood
MH  - Adiponectin/blood
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Neuropathies/blood/*diagnosis/*etiology
MH  - Female
MH  - Heart Diseases/blood/*diagnosis/*etiology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Korea
MH  - Leptin/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC3353195
EDAT- 2012/03/15 06:00
MHDA- 2012/09/19 06:00
PMCR- 2012/03/13
CRDT- 2012/03/15 06:00
PHST- 2011/12/19 00:00 [received]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/03/15 06:00 [entrez]
PHST- 2012/03/15 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
PHST- 2012/03/13 00:00 [pmc-release]
AID - 1475-2840-11-24 [pii]
AID - 10.1186/1475-2840-11-24 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2012 Mar 13;11:24. doi: 10.1186/1475-2840-11-24.