PMID- 22413994
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1755-8166 (Electronic)
IS  - 1755-8166 (Linking)
VI  - 5
DP  - 2012 Mar 14
TI  - Centromeric association of small supernumerary marker chromosomes with their 
      sister-chromosomes detected by three dimensional molecular cytogenetics.
PG  - 15
LID - 10.1186/1755-8166-5-15 [doi]
AB  - BACKGROUND: Small supernumerary marker chromosomes (sSMC) are detected in 0.043% 
      of general population and can be characterized for their chromosomal origin, 
      genetic content and shape by molecular cytogenetic approaches. Even though 
      recently progress was achieved towards genotype-phenotype-correlations of sSMC, 
      nothing is known on the influence that an additional derivative extra chromosome 
      has on the nuclear architecture. RESULTS: Here we present the first 
      three-dimensional interphase fluorescence in situ hybridization (FISH) studies 
      for the nuclear architecture of sSMC. It could be shown that sSMC derived from 
      chromosomes 15, 16 or 18 preferentially colocalized with one of their 
      corresponding sister chromosomes. This was true in B- and T-lymphocytes as well 
      as in skin fibroblasts. Additionally, a case with a complex sSMC with a karyotype 
      47,XY,+der(18)t(8;18)(8p23.2 ~ 23.1;18q11.1) was studied. Here the sSMC 
      co-localized with one homologous chromosome 8 instead of 18. CONCLUSION: Overall, 
      there is a kind of "attraction" between an sSMC and one of its homologous sister 
      chromosomes. This seems to be transmitted by the euchromatic part of the sSMC 
      rather than its heterochromatic one.
FAU - Klein, Elisabeth
AU  - Klein E
AD  - Jena University Hospital, Friedrich Schiller University, Institute of Human 
      Genetics, Kollegiengasse 10, D-07743 Jena, Germany. i8lith@mti.uni-jena.de.
FAU - Manvelyan, Marina
AU  - Manvelyan M
FAU - Simonyan, Isabella
AU  - Simonyan I
FAU - Hamid, Ahmed B
AU  - Hamid AB
FAU - Guilherme, Roberta Santos
AU  - Guilherme RS
FAU - Liehr, Thomas
AU  - Liehr T
FAU - Karamysheva, Tatyana
AU  - Karamysheva T
LA  - eng
PT  - Journal Article
DEP - 20120314
PL  - England
TA  - Mol Cytogenet
JT  - Molecular cytogenetics
JID - 101317942
PMC - PMC3313875
EDAT- 2012/03/15 06:00
MHDA- 2012/03/15 06:01
PMCR- 2012/03/14
CRDT- 2012/03/15 06:00
PHST- 2012/01/18 00:00 [received]
PHST- 2012/03/14 00:00 [accepted]
PHST- 2012/03/15 06:00 [entrez]
PHST- 2012/03/15 06:00 [pubmed]
PHST- 2012/03/15 06:01 [medline]
PHST- 2012/03/14 00:00 [pmc-release]
AID - 1755-8166-5-15 [pii]
AID - 10.1186/1755-8166-5-15 [doi]
PST - epublish
SO  - Mol Cytogenet. 2012 Mar 14;5:15. doi: 10.1186/1755-8166-5-15.