PMID- 22414572
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20120523
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 133
IP  - 5
DP  - 2012 May
TI  - Differential responses of white adipose tissue and brown adipose tissue to 
      caloric restriction in rats.
PG  - 255-66
LID - 10.1016/j.mad.2012.02.003 [doi]
AB  - Caloric restriction (CR) slows the aging process and extends longevity, but the 
      exact underlying mechanisms remain debatable. It has recently been suggested that 
      the beneficial action of CR may be mediated in part by adipose tissue remodeling. 
      Mammals have two types of adipose tissue: white adipose tissue (WAT) and brown 
      adipose tissue (BAT). In this study, proteome analysis using two-dimensional gel 
      electrophoresis combined with MALDI-TOF MS, and subsequent analyses were 
      performed on both WAT and BAT from 9-month-old male rats fed ad libitum or 
      subjected to CR for 6 months. Our findings suggest that CR activates 
      mitochondrial energy metabolism and fatty acid biosynthesis in WAT. It is likely 
      that in CR animals WAT functions as an energy transducer from glucose to 
      energy-dense lipid. In contrast, in BAT CR either had no effect on, or 
      down-regulated, the mitochondrial electron transport chain, but enhanced fatty 
      acid biosynthesis. This suggests that in CR animals BAT may change its function 
      from an energy consuming system to an energy reservoir system. Based on our 
      findings, we conclude that WAT and BAT cooperate to use energy effectively via a 
      differential response of mitochondrial function to CR.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Okita, Naoyuki
AU  - Okita N
AD  - Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Hayashida, Yusuke
AU  - Hayashida Y
FAU - Kojima, Yumiko
AU  - Kojima Y
FAU - Fukushima, Mayumi
AU  - Fukushima M
FAU - Yuguchi, Keiko
AU  - Yuguchi K
FAU - Mikami, Kentaro
AU  - Mikami K
FAU - Yamauchi, Akiko
AU  - Yamauchi A
FAU - Watanabe, Kyoko
AU  - Watanabe K
FAU - Noguchi, Mituru
AU  - Noguchi M
FAU - Nakamura, Megumi
AU  - Nakamura M
FAU - Toda, Toshifusa
AU  - Toda T
FAU - Higami, Yoshikazu
AU  - Higami Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120310
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Fatty Acids)
RN  - 0 (Proteome)
SB  - IM
MH  - Adipose Tissue, Brown/*metabolism
MH  - Adipose Tissue, White/*metabolism
MH  - Animals
MH  - *Caloric Restriction
MH  - Down-Regulation
MH  - Energy Metabolism/physiology
MH  - Fatty Acids/biosynthesis
MH  - Male
MH  - Mitochondria/metabolism
MH  - Proteome
MH  - Rats
MH  - Rats, Wistar
EDAT- 2012/03/15 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/03/15 06:00
PHST- 2011/08/30 00:00 [received]
PHST- 2011/12/14 00:00 [revised]
PHST- 2012/02/22 00:00 [accepted]
PHST- 2012/03/15 06:00 [entrez]
PHST- 2012/03/15 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S0047-6374(12)00035-8 [pii]
AID - 10.1016/j.mad.2012.02.003 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2012 May;133(5):255-66. doi: 10.1016/j.mad.2012.02.003. Epub 
      2012 Mar 10.