PMID- 22415150
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20120430
IS  - 1542-233X (Electronic)
IS  - 1542-2321 (Linking)
VI  - 38
IP  - 3
DP  - 2012 May
TI  - Elevated tear interleukin-6 and interleukin-8 levels associated with silicone 
      hydrogel and conventional hydrogel contact lens wear.
PG  - 146-9
LID - 10.1097/ICL.0b013e3182482910 [doi]
AB  - PURPOSE: The aim of this study was to evaluate the ocular tear interleukin (IL)-6 
      and IL-8 concentrations within the first 6 months of contact lens (CL) wear in 
      eyes of neophyte CL users who had been commenced on either silicone hydrogel CL 
      (SH-CL) or conventional hydrogel CL (CH-CL). METHODS: Twenty-four subjects with 
      no history of CL wear received either SH-CL (n=12) or CH-CL (n=12) for a period 
      of 6 months in this prospective study. Tear IL-6 and IL-8 concentrations were 
      determined before CL wear (0 months) and at 1, 3, and 6 months after CL 
      commencement. The sera of all the subjects were tested and graded (grades 0-6) 
      for grass, weed, and tree pollen-specific immunoglobulin E (IgE) levels. RESULTS: 
      Tear IL-6 concentrations at 0, 1, 3, and 6 months for SH-CL and CH-CL users were 
      7.1 +/- 6.4, 10.5 +/- 8.9, 18.6 +/- 17.0, 33.1 +/- 15.0 pg/mL and 10.9 +/- 8.2, 6.4 +/- 4.0, 
      24.2 +/- 13.2, 34.4 +/- 17.5 pg/mL, respectively. In both groups, IL-6 levels were 
      significantly elevated at 6 months compared with those at 0 months (P<0.001). 
      Tear IL-8 concentrations at 0, 1, 3, and 6 months for SH-CL and CH-CL users were 
      107.4 +/- 56.8, 106.0 +/- 47.4, 319.5 +/- 154.8, 412.6 +/- 104.1 pg/mL and 176.4 +/- 59.7, 
      196.2 +/- 145.0, 410.7 +/- 121.2, 456.7 +/- 19.2 pg/mL, respectively. In both groups, 
      tear IL-8 levels were significantly elevated at 6 months compared with those at 0 
      months (P<0.001). The tear IL-6 and IL-8 levels were found to be similar within 
      the 2 groups at the 6-month time point (P>0.05). The serum grass, weed, and tree 
      pollen-specific IgE levels were similar between groups (P>0.05) and less than 
      0.35 kU/L (grade 0) in 22 of 24 (91.7%) participants tested. CONCLUSIONS: The 
      SH-CL and CH-CL wear is associated with elevation of IL-6 and IL-8 levels in the 
      tears of healthy, nonatopic neophyte CL users.
FAU - Poyraz, Cigdem
AU  - Poyraz C
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey.
FAU - Irkec, Murat
AU  - Irkec M
FAU - Mocan, Mehmet Cem
AU  - Mocan MC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Eye Contact Lens
JT  - Eye & contact lens
JID - 101160941
RN  - 0 (Hydrogels)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Silicone Elastomers)
SB  - IM
MH  - Adult
MH  - Contact Lenses, Extended-Wear/*adverse effects
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hydrogels/*adverse effects
MH  - Interleukin-6/*analysis
MH  - Interleukin-8/*analysis
MH  - Male
MH  - Prospective Studies
MH  - Silicone Elastomers/*adverse effects
MH  - Tears/*chemistry
MH  - Time Factors
MH  - Young Adult
EDAT- 2012/03/15 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/03/15 06:00
PHST- 2012/03/15 06:00 [entrez]
PHST- 2012/03/15 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.1097/ICL.0b013e3182482910 [doi]
PST - ppublish
SO  - Eye Contact Lens. 2012 May;38(3):146-9. doi: 10.1097/ICL.0b013e3182482910.