PMID- 22416902
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20220330
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 19
IP  - 7
DP  - 2012 Jul
TI  - Low molecular weight heparin versus unfractionated heparin in cerebral venous 
      sinus thrombosis: a randomized controlled trial.
PG  - 1030-6
LID - 10.1111/j.1468-1331.2012.03690.x [doi]
AB  - BACKGROUND:   There is no randomized controlled trial (RCT) evaluating the 
      efficacy and safety of low molecular weight heparin (LMWH) compared to 
      unfractionated heparin (UFH) in cerebral venous sinus thrombosis (CVST). In this 
      RCT, we have evaluated the efficacy and safety of LMWH versus UFH in CVST. 
      METHODS:   Consecutive patients with CVST diagnosed on the basis of MR venography 
      (MRV) who was free of bleeding diathesis, malignancy, hepatic or renal failure 
      were prospectively enrolled. History, clinical findings and risk factors were 
      evaluated. MRI and MRV findings were recorded. The patients were randomized to 
      LMWH and UFH groups for 14 days followed by oral anticoagulant. The hospital 
      mortality and 3 months outcome as assessed by Barthel index (BI) score were 
      noted. RESULTS:   32 patients received UFH and 34 received LMWH. The baseline 
      demographic, clinical and radiological parameters were similar in both the 
      groups. Six patients died and all were in UFH group (P = 0.01). At 3 months, 
      insignificantly higher number of patients recovered completely in LMWH compared 
      to UFH group (30 vs. 20). There was no serious side effect needing withdrawal of 
      drugs except one was withdrawn from UFH because of heparin-induced thrombosis. 
      CONCLUSION:   Low molecular weight heparin resulted in significantly lower 
      hospital mortality in CVST compared to UFH.
CI  - (c) 2012 The Author(s) European Journal of Neurology (c) 2012 EFNS.
FAU - Misra, U K
AU  - Misra UK
AD  - Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical 
      Sciences, Lucknow, India. drukmisra@rediffmail.com
FAU - Kalita, J
AU  - Kalita J
FAU - Chandra, S
AU  - Chandra S
FAU - Kumar, B
AU  - Kumar B
FAU - Bansal, V
AU  - Bansal V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120315
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
CIN - Eur J Neurol. 2012 Jul;19(7):933-4. PMID: 22417289
MH  - Adult
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Sinus Thrombosis, Intracranial/*drug therapy/mortality
MH  - Treatment Outcome
EDAT- 2012/03/16 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/03/16 06:00
PHST- 2012/03/16 06:00 [entrez]
PHST- 2012/03/16 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - 10.1111/j.1468-1331.2012.03690.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2012 Jul;19(7):1030-6. doi: 10.1111/j.1468-1331.2012.03690.x. Epub 
      2012 Mar 15.