PMID- 22417572
OWN - NLM
STAT- MEDLINE
DCOM- 20120709
LR  - 20211021
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 11
DP  - 2012 Mar 14
TI  - Genetic diversity and population structure of genes encoding vaccine candidate 
      antigens of Plasmodium vivax.
PG  - 68
LID - 10.1186/1475-2875-11-68 [doi]
AB  - BACKGROUND: A major concern in malaria vaccine development is genetic 
      polymorphisms typically observed among Plasmodium isolates in different 
      geographical areas across the world. Highly polymorphic regions have been 
      observed in Plasmodium falciparum and Plasmodium vivax antigenic surface proteins 
      such as Circumsporozoite protein (CSP), Duffy-binding protein (DBP), Merozoite 
      surface protein-1 (MSP-1), Apical membrane antigen-1 (AMA-1) and Thrombospondin 
      related anonymous protein (TRAP). METHODS: Genetic variability was assessed in 
      important polymorphic regions of various vaccine candidate antigens in P. vivax 
      among 106 isolates from the Amazon Region of Loreto, Peru. In addition, genetic 
      diversity determined in Peruvian isolates was compared to population studies from 
      various geographical locations worldwide. RESULTS: The structured diversity found 
      in P. vivax populations did not show a geographic pattern and haplotypes from all 
      gene candidates were distributed worldwide. In addition, evidence of balancing 
      selection was found in polymorphic regions of the trap, dbp and ama-1 genes. 
      CONCLUSIONS: It is important to have a good representation of the haplotypes 
      circulating worldwide when implementing a vaccine, regardless of the geographic 
      region of deployment since selective pressure plays an important role in 
      structuring antigen diversity.
FAU - Chenet, Stella M
AU  - Chenet SM
AD  - Parasitology Program, Naval Medical Research Unit No, 6, Lima, Peru.
FAU - Tapia, Lorena L
AU  - Tapia LL
FAU - Escalante, Ananias A
AU  - Escalante AA
FAU - Durand, Salomon
AU  - Durand S
FAU - Lucas, Carmen
AU  - Lucas C
FAU - Bacon, David J
AU  - Bacon DJ
LA  - eng
GR  - R01 GM080586/GM/NIGMS NIH HHS/United States
GR  - R01GM80586/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120314
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Malaria Vaccines)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigenic Variation/genetics/immunology
MH  - Antigens, Protozoan/*genetics/immunology
MH  - Asia
MH  - Haplotypes
MH  - Latin America
MH  - Malaria Vaccines/*immunology
MH  - Molecular Sequence Data
MH  - Oceania
MH  - Phylogeography
MH  - Plasmodium vivax/*genetics/immunology/isolation & purification
MH  - Polymorphism, Genetic/*immunology
PMC - PMC3330009
EDAT- 2012/03/16 06:00
MHDA- 2012/07/10 06:00
PMCR- 2012/03/14
CRDT- 2012/03/16 06:00
PHST- 2011/12/19 00:00 [received]
PHST- 2012/03/14 00:00 [accepted]
PHST- 2012/03/16 06:00 [entrez]
PHST- 2012/03/16 06:00 [pubmed]
PHST- 2012/07/10 06:00 [medline]
PHST- 2012/03/14 00:00 [pmc-release]
AID - 1475-2875-11-68 [pii]
AID - 10.1186/1475-2875-11-68 [doi]
PST - epublish
SO  - Malar J. 2012 Mar 14;11:68. doi: 10.1186/1475-2875-11-68.