PMID- 22421065
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20191210
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 198
IP  - 3
DP  - 2012 Aug 15
TI  - One-year functional outcomes of naturalistically treated patients with 
      schizophrenia.
PG  - 378-85
LID - S0165-1781(12)00005-4 [pii]
LID - 10.1016/j.psychres.2011.12.047 [doi]
AB  - Against the background of the growing evidence that the patient's functioning 
      significantly influences the course and outcome of schizophrenia, the aims of 
      this analysis were to examine what proportion of patients achieve functional 
      outcome criteria after 1 year, and to identify clinical and sociodemographic 
      predictive factors for functional remission. Patients with the diagnosis of 
      schizophrenia who were treated as inpatients at the beginning of the study were 
      examined within a naturalistic follow-up trial. The present study reports on the 
      time frame from admission to discharge of an inpatient treatment period and the 
      1-year follow-up assessment. The Global Assessment of Functioning (GAF) Scale and 
      Social and Occupational Functioning Assessment Scale (SOFAS) were evaluated with 
      respect to functional outcome, whereas Positive and Negative Syndrome Scale 
      (PANSS) scores were rated as psychopathological outcome measures. Functional 
      remission thresholds were defined according to a GAF score of >/=61 points and a 
      SOFAS score >/=61 points. Symptomatic remission criteria were applied according to 
      the remission criteria of the Schizophrenia Working Group. The Strauss-Carpenter 
      Prognostic Scale (SCPS), the Phillips Premorbid Adjustment Scale, medical 
      history, sociodemographic and psychopathologic parameters were evaluated in order 
      to find valuable predictors for functional remission. One year after discharge 
      from inpatient treatment, 211 out of 474 patients were available for analysis 
      according to both rating scales used to assess functional remission (GAF and 
      SOFAS). Forty-seven percent of patients fulfilled criteria for functional 
      remission (GAF and SOFAS) at discharge and 51% of patients at the 1-year 
      follow-up visit. With regard to symptomatic remission criteria, the corresponding 
      remitter rates were 61% of patients at discharge and 54% at the 1-year follow-up 
      visit. Forty-two percent of patients fulfilled both remission criteria at 
      discharge and 37% at the 1-year follow-up visit. A significant association was 
      found between functional and symptomatic remission at discharge and at the 1-year 
      follow-up visit. The strongest predictors for functional remission at the 1-year 
      follow-up visit were: a higher SCPS total score at admission, a lower number of 
      previous hospitalizations, a status of employment, lower scores in all PANSS 
      subscales at discharge, a better premorbid social adjustment, the occurrence of a 
      first psychotic episode, a younger age, a lower PANSS negative subscore at 
      admission, a status of being an early responder, a shorter duration of inpatient 
      treatment, a later age of onset, and female gender.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Spellmann, Ilja
AU  - Spellmann I
AD  - Psychiatrische Klinik der LMU Munchen, Nussbaumstr. 7, 80336 Munchen, Germany. 
      ilja.spellmann@med.uni-muenchen.de
FAU - Riedel, Michael
AU  - Riedel M
FAU - Schennach, Rebecca
AU  - Schennach R
FAU - Seemuller, Felix
AU  - Seemuller F
FAU - Obermeier, Michael
AU  - Obermeier M
FAU - Musil, Richard
AU  - Musil R
FAU - Jager, Markus
AU  - Jager M
FAU - Schmauss, Max
AU  - Schmauss M
FAU - Laux, Gerd
AU  - Laux G
FAU - Pfeiffer, Herbert
AU  - Pfeiffer H
FAU - Naber, Dieter
AU  - Naber D
FAU - Schmidt, Lutz G
AU  - Schmidt LG
FAU - Gaebel, Wolfgang
AU  - Gaebel W
FAU - Klosterkotter, Joachim
AU  - Klosterkotter J
FAU - Heuser, Isabella
AU  - Heuser I
FAU - Maier, Wolfgang
AU  - Maier W
FAU - Lemke, Matthias R
AU  - Lemke MR
FAU - Ruther, Eckart
AU  - Ruther E
FAU - Klingberg, Stefan
AU  - Klingberg S
FAU - Gastpar, Markus
AU  - Gastpar M
FAU - Moller, Hans-Jurgen
AU  - Moller HJ
LA  - eng
PT  - Journal Article
DEP - 20120314
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/statistics & numerical data
MH  - Outpatients
MH  - Prognosis
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Remission Induction/methods
MH  - Schizophrenia/*diagnosis/*therapy
MH  - *Schizophrenic Psychology
EDAT- 2012/03/17 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/03/17 06:00
PHST- 2011/07/31 00:00 [received]
PHST- 2011/12/02 00:00 [revised]
PHST- 2011/12/30 00:00 [accepted]
PHST- 2012/03/17 06:00 [entrez]
PHST- 2012/03/17 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - S0165-1781(12)00005-4 [pii]
AID - 10.1016/j.psychres.2011.12.047 [doi]
PST - ppublish
SO  - Psychiatry Res. 2012 Aug 15;198(3):378-85. doi: 10.1016/j.psychres.2011.12.047. 
      Epub 2012 Mar 14.