PMID- 22421187
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20120528
IS  - 1532-2769 (Electronic)
IS  - 1356-689X (Linking)
VI  - 17
IP  - 4
DP  - 2012 Aug
TI  - Spinal manual therapy produces rapid onset analgesia in a rodent model.
PG  - 292-7
LID - 10.1016/j.math.2012.02.004 [doi]
AB  - A rapid hypoalgesic effect following spinal manual therapy (SMT) has been 
      demonstrated in humans. Although the characteristics of the pain relief are well 
      described, the mechanisms have remained speculative. The purpose of this suite of 
      studies was to investigate the effects of SMT on pain measures using animal 
      models. This study employed a randomized, controlled design. Study 1: Rats 
      without inflammation were allocated to either a treatment group (n = 6) that 
      received three applications of joint mobilization centrally over L5 or a 
      sham-treated group (n = 6) who received non-specific handling. Pressure pain 
      threshold (PPT) and thermal pain threshold (TPT) were measured before and 
      immediately after each intervention. Results demonstrated significantly increased 
      mechanical nociceptive thresholds in the SMT group (p = 0.01) compared to that of 
      the sham-treated group but no difference for thermal nociceptive thresholds. 
      Study 2: The time course effect of an inflammatory and mechanical response 
      following i.pl injection of inflammatory mediators was investigated to determine 
      the appropriate time period for a treatment intervention. Study 3: The effects of 
      SMT on mechanical nociception were investigated following interplanar injection 
      of inflammatory mediators into the right hind paw of rats as a pain model (n = 6 
      for both SMT and sham-treated groups). Injection of endogenous metabolites 
      produced significant swelling and flaring as well as increased PPT values 
      following SMT (p < 0.02) compared with controls. These results demonstrate a 
      rapid analgesic response following application of SMT, which has similar 
      characteristics as that seen in both symptomatic and asymptomatic human 
      populations.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Grayson, Jane E
AU  - Grayson JE
AD  - School of Physiotherapy and Exercise Science, Griffith University, Gold Coast, 
      Queensland 4222, Australia. j.grayson@griffith.edu.au
FAU - Barton, Tom
AU  - Barton T
FAU - Cabot, Peter J
AU  - Cabot PJ
FAU - Souvlis, Tina
AU  - Souvlis T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120314
PL  - Scotland
TA  - Man Ther
JT  - Manual therapy
JID - 9610924
SB  - IM
MH  - Analgesia/methods
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Inflammation/*rehabilitation
MH  - *Lumbar Vertebrae
MH  - Male
MH  - Manipulation, Spinal/*methods
MH  - Pain/rehabilitation
MH  - Pain Measurement
MH  - Pain Threshold/*physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Sensitivity and Specificity
MH  - Time Factors
EDAT- 2012/03/17 06:00
MHDA- 2012/10/20 06:00
CRDT- 2012/03/17 06:00
PHST- 2011/08/09 00:00 [received]
PHST- 2012/02/02 00:00 [revised]
PHST- 2012/02/07 00:00 [accepted]
PHST- 2012/03/17 06:00 [entrez]
PHST- 2012/03/17 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - S1356-689X(12)00034-3 [pii]
AID - 10.1016/j.math.2012.02.004 [doi]
PST - ppublish
SO  - Man Ther. 2012 Aug;17(4):292-7. doi: 10.1016/j.math.2012.02.004. Epub 2012 Mar 
      14.