PMID- 22421318
OWN - NLM
STAT- MEDLINE
DCOM- 20120912
LR  - 20220321
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 45
IP  - 9
DP  - 2012 Jun
TI  - Clinical significance of inflammatory and fibrogenic cytokines in diabetic 
      nephropathy.
PG  - 646-50
LID - 10.1016/j.clinbiochem.2012.02.021 [doi]
AB  - OBJECTIVES: To study the role of inflammatory chemokine; monocyte chemoattractant 
      protein-1 (MCP-1), and fibrogenic markers [transforming growth factor beta-1 
      (TGF-beta(1)), connective tissue growth factor (CTGF) and fibronectin (FN)] in 
      diabetic nephropathy (DN). DESIGN AND METHODS: This study included 17 control and 
      65 type 2 diabetic subjects (18 normoalbuminuric, 22 microalbuminuric and 25 
      macroalbuminuric). Demographic characteristics, diabetic index and kidney 
      function tests were monitored. Serum TGF-beta(1), plasma CTGF, MCP-1 and FN levels 
      were assayed. RESULTS: Microalbuminuric and macroalbuminuric subjects showed a 
      significant elevation in TGF-beta(1), CTGF, MCP-1 and FN levels as compared with 
      control and normoalbuminuric subjects. There was positive correlation between 
      these markers and fasting plasma glucose, albumin excretion rate and with each 
      other. CONCLUSION: This study revealed the importance of these markers in DN 
      pathogenesis which is powered by their association and thus the possibility of 
      their use as biochemical markers in DN was suggested.
CI  - Copyright (c) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - El Mesallamy, Hala O
AU  - El Mesallamy HO
AD  - Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Egypt.
FAU - Ahmed, Hanaa H
AU  - Ahmed HH
FAU - Bassyouni, Atef A
AU  - Bassyouni AA
FAU - Ahmed, Amira S
AU  - Ahmed AS
LA  - eng
PT  - Journal Article
DEP - 20120306
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCN2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Fibronectins)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 139568-91-5 (Connective Tissue Growth Factor)
SB  - IM
MH  - Adult
MH  - Albuminuria/*blood/complications/physiopathology
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Connective Tissue Growth Factor/*blood
MH  - Diabetes Mellitus, Type 2/*blood/complications/physiopathology
MH  - Diabetic Nephropathies/*blood/complications/physiopathology
MH  - Female
MH  - Fibronectins/*blood
MH  - Fibrosis/blood
MH  - Humans
MH  - Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Transforming Growth Factor beta1/*blood
EDAT- 2012/03/17 06:00
MHDA- 2012/09/13 06:00
CRDT- 2012/03/17 06:00
PHST- 2011/06/27 00:00 [received]
PHST- 2012/02/17 00:00 [revised]
PHST- 2012/02/25 00:00 [accepted]
PHST- 2012/03/17 06:00 [entrez]
PHST- 2012/03/17 06:00 [pubmed]
PHST- 2012/09/13 06:00 [medline]
AID - S0009-9120(12)00098-7 [pii]
AID - 10.1016/j.clinbiochem.2012.02.021 [doi]
PST - ppublish
SO  - Clin Biochem. 2012 Jun;45(9):646-50. doi: 10.1016/j.clinbiochem.2012.02.021. Epub 
      2012 Mar 6.