PMID- 22421463
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20151119
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 61
IP  - 8
DP  - 2012 Aug
TI  - Carbohydrate supplementation increases intramyocellular lipid stores in elite 
      runners.
PG  - 1189-96
LID - 10.1016/j.metabol.2012.01.013 [doi]
AB  - The objective was to determine the effects of carbohydrate (CHO) supplementation 
      on exercise-induced hormone responses and post-training intramyocellular lipid 
      stores (IMCL). Twenty-four elite male athletes (28.0+/-1.2 years) were randomized 
      to receive CHO (maltodextrin solution) or zero energy placebo solution (control 
      group). The high-intensity running protocol consisted of 10x800 m at 100% of the 
      best 3000-m speed (Vm3 km) and 2x1000 m maximal bouts in the morning and a 
      submaximal 10-km continuous easy running in the afternoon of day 9. IMCL 
      concentrations were assessed by (1)H-MRS before (-day 9) and after training (day 
      9) in soleus (SO) and tibialis anterior (TA) muscles. Blood hormones were also 
      measured before, during, and post-exercise. The percent change (Delta%) in TA-IMCL 
      was higher in the CHO group (47.9+/-24.5 IMCL/Cr) than in the control group 
      (-1.7+/-13.1, respectively) (P=.04). Insulin concentrations were higher in the CHO 
      group post-intermittent running compared to control (P=.02). Circulating levels 
      of free fatty acids and GH were lower in the CHO group (P>.01). The decline in 
      performance in the 2nd 1000-m bout was also attenuated in this group compared to 
      control (P<.001 and P=.0035, respectively). The hormonal milieu (higher insulin 
      and lower GH levels) in the CHO group, together with unchanged free fatty acid 
      levels, probably contributed to the increased IMCL stores. This greater energy 
      storage capacity may have improved post-exercise recovery and thus prevented 
      performance deterioration.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Sousa, Maysa
AU  - Sousa M
AD  - Laboratory of Medical Investigation LIM-18, Faculty of Medicine, University of 
      Sao Paulo, Av. Dr. Arnaldo 455, Sao Paulo, SP, Brazil. maysavs@uol.com.br
FAU - Simoes, Herbert Gustavo
AU  - Simoes HG
FAU - Castro, Claudio Campi de
AU  - Castro CC
FAU - Otaduy, Maria Concepcion Garcia
AU  - Otaduy MC
FAU - Negrao, Carlos Eduardo
AU  - Negrao CE
FAU - Pereira, Rosa Maria Rodrigues
AU  - Pereira RM
FAU - Madsen, Klavs
AU  - Madsen K
FAU - Silva, Maria Elizabeth Rossi da
AU  - Silva ME
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120314
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adiponectin/blood
MH  - Adult
MH  - *Athletes
MH  - Biomarkers/blood
MH  - Dietary Carbohydrates/*administration & dosage/*metabolism
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Epinephrine/blood
MH  - Fatty Acids, Nonesterified/blood
MH  - Human Growth Hormone/blood
MH  - Humans
MH  - Insulin/blood
MH  - *Lipid Metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Muscle Cells/*metabolism
MH  - Muscle, Skeletal/*metabolism
MH  - *Running
EDAT- 2012/03/17 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/03/17 06:00
PHST- 2011/10/15 00:00 [received]
PHST- 2012/01/06 00:00 [revised]
PHST- 2012/01/17 00:00 [accepted]
PHST- 2012/03/17 06:00 [entrez]
PHST- 2012/03/17 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S0026-0495(12)00041-8 [pii]
AID - 10.1016/j.metabol.2012.01.013 [doi]
PST - ppublish
SO  - Metabolism. 2012 Aug;61(8):1189-96. doi: 10.1016/j.metabol.2012.01.013. Epub 2012 
      Mar 14.