PMID- 2242162
OWN - NLM
STAT- MEDLINE
DCOM- 19901109
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 63
IP  - 1
DP  - 1990 Oct 5
TI  - The single-minded gene of Drosophila is required for the expression of genes 
      important for the development of CNS midline cells.
PG  - 63-75
AB  - The single-minded (sim) gene of Drosophila encodes a nuclear protein that plays a 
      critical role in the development of the neurons, glia, and other nonneuronal 
      cells that lie along the midline of the embryonic CNS. Using distinct cell fate 
      markers, we observe that in sim mutant embryos the midline cells fail to 
      differentiate properly into their mature CNS cell types and do not take their 
      appropriate positions within the developing CNS. We further present evidence that 
      sim is required for midline expression of a group of genes including slit, Toll, 
      rhomboid, engrailed, and a gene at 91F; that the sim mutant CNS defect may be 
      largely due to loss of midline slit expression; and that the snail gene is 
      required to repress sim and other midline genes in the presumptive mesoderm.
FAU - Nambu, J R
AU  - Nambu JR
AD  - Department of Biology, University of California, Los Angeles 90024.
FAU - Franks, R G
AU  - Franks RG
FAU - Hu, S
AU  - Hu S
FAU - Crews, S T
AU  - Crews ST
LA  - eng
GR  - GM 07104/GM/NIGMS NIH HHS/United States
GR  - R01 HD25251/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
SB  - IM
GS  - sim
MH  - Animals
MH  - Drosophila/embryology/*genetics
MH  - Embryo, Nonmammalian/physiology
MH  - Gene Expression Regulation
MH  - *Genes
MH  - Mutation
MH  - Nervous System/cytology/embryology
MH  - Phenotype
EDAT- 1990/10/05 00:00
MHDA- 1990/10/05 00:01
CRDT- 1990/10/05 00:00
PHST- 1990/10/05 00:00 [pubmed]
PHST- 1990/10/05 00:01 [medline]
PHST- 1990/10/05 00:00 [entrez]
AID - 0092-8674(90)90288-P [pii]
AID - 10.1016/0092-8674(90)90288-p [doi]
PST - ppublish
SO  - Cell. 1990 Oct 5;63(1):63-75. doi: 10.1016/0092-8674(90)90288-p.