PMID- 22421698
OWN - NLM
STAT- MEDLINE
DCOM- 20120718
LR  - 20211021
IS  - 1537-4521 (Electronic)
IS  - 0148-5717 (Print)
IS  - 0148-5717 (Linking)
VI  - 39
IP  - 4
DP  - 2012 Apr
TI  - Incidence, prevalence, and epidemiology of herpes simplex virus-2 in 
      HIV-1-positive and HIV-1-negative adolescents.
PG  - 300-5
LID - 10.1097/OLQ.0b013e318244a90f [doi]
AB  - BACKGROUND: Several studies have assessed risk factors associated with herpes 
      simplex virus-2 (HSV-2) prevalence in adults; however, few have focused on HSV-2 
      incidence, particularly in adolescents. The objective of this study was to 
      determine HSV-2 prevalence and incidence and associated risk factors in a 
      HIV-1-positive and at risk HIV-1-negative adolescent population. METHODS: Sera 
      were tested for HSV-2 antibodies in 518 adolescents in the Reaching for 
      Excellence in Adolescent Care and Health cohort at baseline and again at the 
      final follow-up visit. Prevalence at baseline and incidence (per person years) of 
      HSV-2 infection were calculated. Furthermore, among HIV-1-positive individuals, a 
      subgroup analysis was performed to assess risk factors for HSV-2 infection. 
      Conditional logistic regression was used to estimate odds ratios and P values for 
      associations between CD4+ T-cell (CD4+) count, HIV-1 viral load (VL), and HSV-2 
      acquisition, adjusting for antiretroviral therapy use, other sexually transmitted 
      infections, gender, race, and number of sexual partners. RESULTS: At baseline, 
      179 (35%) subjects were HSV-2 positive, with an additional 47 (16%) new cases 
      being identified during a median follow-up time of 1.95 years and an incidence 
      rate of 7.35 cases per 100 person years. Several risk factors were associated 
      with HSV-2 prevalence (being female, non-Hispanic, uncertainty of sexual 
      preference, and HIV-1 positive) and incidence (using drugs, alcohol, and number 
      of new sexual partners). Among HIV-1 positives, an increase in CD4+ count by 50 
      cell/mm(3) (odds ratio, 1.17; 95% CI, 1.04-1.31, P = 0.008) was associated with 
      HSV-2 acquisition. CONCLUSIONS: The high prevalence and incidence of HSV-2 
      infection among adolescents, compared with the general population at this age 
      group suggests a critical need for screening and preventive programs among this 
      targeted group.
FAU - Sudenga, Staci L
AU  - Sudenga SL
AD  - Department of Epidemiology, School of Public Health, University of Alabama at 
      Birmingham, Birmingham, Alabama 35294-0022, USA.
FAU - Kempf, Mirjam-Colette
AU  - Kempf MC
FAU - McGwin, Gerald Jr
AU  - McGwin G Jr
FAU - Wilson, Craig M
AU  - Wilson CM
FAU - Hook, Edward W 3rd
AU  - Hook EW 3rd
FAU - Shrestha, Sadeep
AU  - Shrestha S
LA  - eng
GR  - P30 AI027767/AI/NIAID NIH HHS/United States
GR  - 5P30 AI27767-20/AI/NIAID NIH HHS/United States
GR  - R25 CA047888/CA/NCI NIH HHS/United States
GR  - R25 CA047888-23/CA/NCI NIH HHS/United States
GR  - U01 HD032830-07/HD/NICHD NIH HHS/United States
GR  - R25CA47888/CA/NCI NIH HHS/United States
GR  - P30 AI027767-20/AI/NIAID NIH HHS/United States
GR  - U01-HD32830/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Sex Transm Dis
JT  - Sexually transmitted diseases
JID - 7705941
SB  - IM
MH  - Adolescent
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - HIV Seronegativity
MH  - HIV Seropositivity/*epidemiology/immunology
MH  - HIV-1/*isolation & purification
MH  - Herpes Genitalis/*epidemiology/immunology
MH  - Herpesvirus 2, Human/*isolation & purification
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Odds Ratio
MH  - Prevalence
MH  - Risk Factors
MH  - Sexual Behavior/*statistics & numerical data
MH  - Viral Load
PMC - PMC3306602
MID - NIHMS347308
EDAT- 2012/03/17 06:00
MHDA- 2012/07/19 06:00
PMCR- 2013/04/01
CRDT- 2012/03/17 06:00
PHST- 2012/03/17 06:00 [entrez]
PHST- 2012/03/17 06:00 [pubmed]
PHST- 2012/07/19 06:00 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - 00007435-201204000-00011 [pii]
AID - 10.1097/OLQ.0b013e318244a90f [doi]
PST - ppublish
SO  - Sex Transm Dis. 2012 Apr;39(4):300-5. doi: 10.1097/OLQ.0b013e318244a90f.