PMID- 22422192
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20240330
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Print)
IS  - 0340-6199 (Linking)
VI  - 171
IP  - 7
DP  - 2012 Jul
TI  - Clinical practice : coeliac disease.
PG  - 1011-21
LID - 10.1007/s00431-012-1714-8 [doi]
AB  - Coeliac disease (CD) is an immune-mediated systemic condition elicited by gluten 
      and related prolamines in genetically predisposed individuals and characterised 
      by gluten-induced symptoms and signs, specific antibodies, a specific human 
      leukocyte antigen (HLA) type and enteropathy. The risk of coeliac disease is 
      increased in first-degree relatives, certain syndromes including Down syndrome 
      and autoimmune disorders. It is thought to occur in 1 in 100-200 individuals, but 
      still only one in four cases is diagnosed. Small-bowel biopsy is no longer deemed 
      necessary in a subgroup of patients, i.e. when all of the following are present: 
      typical symptoms or signs, high titres of and transglutaminase antibodies, 
      endomysial antibodies, and HLA-type DQ2 or DQ8. In all other cases, small-bowel 
      biopsy remains mandatory for a correct diagnosis. Therapy consists of a strictly 
      gluten-free diet. This should result in complete disappearance of symptoms and of 
      serological markers. Adequate follow-up is considered essential. CONCLUSION: 
      Although small-bowel biopsy may be omitted in a minority of patients, small-bowel 
      biopsy is essential for a correct diagnosis of CD in all other cases. Diagnostic 
      work-up should be completed before treatment with gluten-free diet instituted.
FAU - Kneepkens, C M Frank
AU  - Kneepkens CM
AD  - Department of Paediatrics, VU University Medical Centre, De Boelelaan 1117, 1081 
      HV, Amsterdam, The Netherlands. cmf.kneepkens@vumc.nl
FAU - von Blomberg, B Mary E
AU  - von Blomberg BM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120316
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
SB  - IM
MH  - Biopsy
MH  - *Celiac Disease/diagnosis/diet therapy/epidemiology/physiopathology
MH  - Diet, Gluten-Free
MH  - Humans
MH  - Incidence
MH  - Intestine, Small/pathology
MH  - Netherlands/epidemiology
MH  - Prognosis
PMC - PMC3378840
EDAT- 2012/03/17 06:00
MHDA- 2012/10/26 06:00
PMCR- 2012/03/16
CRDT- 2012/03/17 06:00
PHST- 2012/02/21 00:00 [received]
PHST- 2012/02/28 00:00 [accepted]
PHST- 2012/03/17 06:00 [entrez]
PHST- 2012/03/17 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PHST- 2012/03/16 00:00 [pmc-release]
AID - 1714 [pii]
AID - 10.1007/s00431-012-1714-8 [doi]
PST - ppublish
SO  - Eur J Pediatr. 2012 Jul;171(7):1011-21. doi: 10.1007/s00431-012-1714-8. Epub 2012 
      Mar 16.