PMID- 22424067
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20131121
IS  - 1532-4109 (Electronic)
IS  - 0360-1234 (Linking)
VI  - 47
IP  - 5
DP  - 2012
TI  - Developmental exposure to diuron causes splenotoxicity in male Sprague-Dawley rat 
      pups.
PG  - 420-6
LID - 10.1080/03601234.2012.657054 [doi]
AB  - This study investigated whether perinatal exposure to diuron 
      [3-(3,4-dichlorophenyl)-1-1-dimethylurea] might exert adverse effects on rat 
      lymphoid organs. Pregnant Sprague-Dawley (SD) rats were exposed to diuron at 500, 
      750 or 1250 ppm in the diet from gestational days (GD) 12-21 and during 
      lactation. At postnatal day (PND) 42, male pups were euthanized and thymus, 
      spleen, mesenteric lymph node and femur were collected for histopathological 
      analysis. Food consumption and body weight gain were significantly reduced in 
      dams exposed to 1250 ppm during gestation period. Also, Diuron at 750 and 1250 
      ppm produced: (1) increased relative spleen weight associated histologically with 
      severe congestion in red pulp, (2) enhanced extramedullary hematopoiesis and 
      hemosiderosis as well as (3) depletion of lymphoid follicles in white pulp. Flow 
      cytometric analysis revealed a significant reduction in B lymphocytes (CD45RA+) 
      in male pups but T lymphocytes (CD4+, CD8+ and CD4+/CD8+) were not markedly 
      affected. Thus, data suggest that Diuron-induced maternal toxicity in dams 
      exposed to high dose and perinatal exposure to this herbicide produced spleen 
      toxicity as evidenced by a reduction in B lymphocyte number in male SD pups.
FAU - Domingues, Alexandre
AU  - Domingues A
AD  - School of Medicine, UNESP-Universidade Estadual Paulista, Sao Paulo, Brazil.
FAU - Grassi, Tony F
AU  - Grassi TF
FAU - Spinardi-Barbisan, Ana L T
AU  - Spinardi-Barbisan AL
FAU - Barbisan, Luis F
AU  - Barbisan LF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Environ Sci Health B
JT  - Journal of environmental science and health. Part. B, Pesticides, food 
      contaminants, and agricultural wastes
JID - 7607167
RN  - 9I3SDS92WY (Diuron)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/growth & development/immunology
MH  - Body Weight
MH  - Bone Marrow/drug effects/growth & development/immunology
MH  - Diuron/*toxicity
MH  - Female
MH  - Growth and Development/*drug effects
MH  - Humans
MH  - Lymphocytes/drug effects/immunology
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Organ Size
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/etiology/immunology/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Species Specificity
MH  - Spleen/*drug effects/growth & development/immunology
EDAT- 2012/03/20 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/03/20 06:00
PHST- 2012/03/20 06:00 [entrez]
PHST- 2012/03/20 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - 10.1080/03601234.2012.657054 [doi]
PST - ppublish
SO  - J Environ Sci Health B. 2012;47(5):420-6. doi: 10.1080/03601234.2012.657054.