PMID- 22424555
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20191112
IS  - 1875-5631 (Electronic)
IS  - 1566-5232 (Linking)
VI  - 12
IP  - 2
DP  - 2012 Apr 1
TI  - Viral and non-viral methods to genetically modify dendritic cells.
PG  - 127-36
AB  - Dendritic cells (DCs) behave as antigenic or tolerogenic immune response inducers 
      depending on the nature of their precursors, their differentiation pathway and 
      their environment. As professional antigen presenting cells (APCs) it has been 
      tempting to genetically modify them in order to improve their capacity to mount 
      appropriate protective immune responses. Gene transfer may also be helpful to 
      investigate fundamental issues about the DC biology. Of note, almost all 
      strategies to deliver genes or interfering RNA into DCs have been used with 
      different success rates. These methods are non-exhaustively presented and 
      discussed here. We focused our attention on promising in vitro as well as in vivo 
      lentiviral- mediated gene delivery solutions into murine or human DCs.
FAU - Humbert, Jean-Marc
AU  - Humbert JM
AD  - UMR_S INSERM Center for Research in Transplantation and Immunology, Institute for 
      Transplantation, Urology and Nephrology, Universite de Nantes, France.
FAU - Halary, Franck
AU  - Halary F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Gene Ther
JT  - Current gene therapy
JID - 101125446
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/*metabolism
MH  - *Gene Transfer Techniques
MH  - Genetic Therapy/methods
MH  - Genetic Vectors/genetics
MH  - Humans
MH  - Immunotherapy/methods
MH  - Lentivirus/*genetics
MH  - Mice
EDAT- 2012/03/20 06:00
MHDA- 2012/08/09 06:00
CRDT- 2012/03/20 06:00
PHST- 2012/03/09 00:00 [received]
PHST- 2012/03/13 00:00 [revised]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/03/20 06:00 [entrez]
PHST- 2012/03/20 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - CGT-EPUB-20120314-002 [pii]
AID - 10.2174/156652312800099580 [doi]
PST - ppublish
SO  - Curr Gene Ther. 2012 Apr 1;12(2):127-36. doi: 10.2174/156652312800099580.