PMID- 22424873
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20131121
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 201
IP  - 2
DP  - 2012 Feb 28
TI  - Abnormal functional connectivity between the anterior cingulate and the default 
      mode network in drug-naive boys with attention deficit hyperactivity disorder.
PG  - 120-7
LID - 10.1016/j.pscychresns.2011.07.001 [doi]
AB  - A previous study indicated that adults with attention deficit hyperactivity 
      disorder (ADHD) had a decreased anti-correlation between the dorsal anterior 
      cingulate cortex (dACC) and the default mode network (DMN). In this study, we 
      investigated whether children with ADHD also show a decreased anti-correlation 
      between the dACC and the DMN. We also explored the developmental characteristics 
      of the resting-state functional connectivity (RSFC) of the dACC with the DMN in 
      children with ADHD. Resting-state functional magnetic resonance imaging scans 
      were obtained from a 3T scanner in 19 drug-naive boys with ADHD and 23 controls. 
      Compared with normal controls, the dACC in boys with ADHD showed a significantly 
      decreased negative RSFC with the DMN, including the dorsomedial prefrontal cortex 
      and the posterior cingulate cortex. The RSFC strength between the dACC and the 
      posterior cingulate cortex showed a significantly negative correlation with age 
      in normal controls, but not in boys with ADHD. This decreased anti-correlation 
      may suggest an abnormal balance or interaction between attentional and intrinsic 
      thoughts. Our age-related analysis suggested an abnormal development pattern of 
      the dACC-DMN interaction in ADHD.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Sun, Li
AU  - Sun L
AD  - Institute of Mental Health, Peking University, Beijing 100191, China.
FAU - Cao, Qingjiu
AU  - Cao Q
FAU - Long, Xiangyu
AU  - Long X
FAU - Sui, Manqiu
AU  - Sui M
FAU - Cao, Xiaohua
AU  - Cao X
FAU - Zhu, Chaozhe
AU  - Zhu C
FAU - Zuo, Xinian
AU  - Zuo X
FAU - An, Li
AU  - An L
FAU - Song, Yan
AU  - Song Y
FAU - Zang, Yufeng
AU  - Zang Y
FAU - Wang, Yufeng
AU  - Wang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120315
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Attention Deficit Disorder with Hyperactivity/diagnosis/*physiopathology
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - Child
MH  - Dominance, Cerebral/physiology
MH  - Gyrus Cinguli/*physiopathology
MH  - Humans
MH  - *Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Oxygen/*blood
MH  - Prefrontal Cortex/physiopathology
EDAT- 2012/03/20 06:00
MHDA- 2012/06/07 06:00
CRDT- 2012/03/20 06:00
PHST- 2010/05/04 00:00 [received]
PHST- 2011/06/29 00:00 [revised]
PHST- 2011/07/01 00:00 [accepted]
PHST- 2012/03/20 06:00 [entrez]
PHST- 2012/03/20 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - S0925-4927(11)00241-1 [pii]
AID - 10.1016/j.pscychresns.2011.07.001 [doi]
PST - ppublish
SO  - Psychiatry Res. 2012 Feb 28;201(2):120-7. doi: 10.1016/j.pscychresns.2011.07.001. 
      Epub 2012 Mar 15.