PMID- 22424903
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20121112
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 198
IP  - 3
DP  - 2012 Aug 15
TI  - Abnormal recovery function of somatosensory evoked potentials in patients with 
      primary insomnia.
PG  - 463-7
LID - S0165-1781(11)00781-5 [pii]
LID - 10.1016/j.psychres.2011.11.024 [doi]
AB  - Neurobiological correlates underlying insomnia are poorly understood. The 
      hyperarousal of the central nervous system indicates that cortical excitability 
      may be abnormal in patients with insomnia. The purpose of the present study was 
      to investigate changes in cortical excitability by examining the recovery 
      function of median nerve somatosensory evoked potentials (SEPs) in patients with 
      primary insomia (PI). We studied the recovery function of median nerve SEPs in 12 
      medication-naive PI patients and in 12 age- and sex-matched healthy subjects. 
      SEPs in response to single stimulus and paired stimuli at interstimulus intervals 
      (ISIs) of 20, 60, 100 and 150 ms were recorded. The recovery function of the 
      cortical components of frontal P20 and parietal N20 showed significantly reduced 
      suppression in PI patients as compared to healthy controls. In conclusion, this 
      is the first study investigating changes in cortical excitability in PI patients 
      by examining the recovery function of median nerve SEPs. The present study 
      suggests that cortical excitability is increased in PI patients. Dysfunction of 
      inhibitory GABAergic interneurons of the cerebral cortex might contribute to the 
      increased cortical excitability in PI patients.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Huang, Zhaoyang
AU  - Huang Z
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 
      Changchunjie Road, Beijing 100053, China.
FAU - Zhan, Shuqin
AU  - Zhan S
FAU - Li, Ning
AU  - Li N
FAU - Ding, Yan
AU  - Ding Y
FAU - Wang, Yuping
AU  - Wang Y
LA  - eng
PT  - Journal Article
DEP - 20120316
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Electric Stimulation/methods
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Median Nerve/physiology
MH  - Recovery of Function/*physiology
MH  - Sleep Initiation and Maintenance Disorders/*physiopathology
MH  - Somatosensory Cortex/*physiopathology
EDAT- 2012/03/20 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/03/20 06:00
PHST- 2011/01/27 00:00 [received]
PHST- 2011/11/13 00:00 [revised]
PHST- 2011/11/26 00:00 [accepted]
PHST- 2012/03/20 06:00 [entrez]
PHST- 2012/03/20 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - S0165-1781(11)00781-5 [pii]
AID - 10.1016/j.psychres.2011.11.024 [doi]
PST - ppublish
SO  - Psychiatry Res. 2012 Aug 15;198(3):463-7. doi: 10.1016/j.psychres.2011.11.024. 
      Epub 2012 Mar 16.