PMID- 2242505
OWN - NLM
STAT- MEDLINE
DCOM- 19910103
LR  - 20191022
IS  - 0742-0528 (Print)
IS  - 0742-0528 (Linking)
VI  - 7
IP  - 2
DP  - 1990
TI  - Effect of chronic caloric restriction on the synchronization of various 
      physiological measures in old female Fischer 344 rats.
PG  - 113-24
AB  - A variety of physiological and behavioral parameters which relate to metabolism 
      were continuously monitored in 18 month old female Fischer 344 rats which were 
      maintained on either ad libitum or reduced calorie diets. Caloric restriction 
      (CR) stimulated average motor activity per day, the duration of each feeding 
      episode, food consumed per episode, and water consumed per gram lean body mass 
      (LBM). However, CR limited total food consumption, feeding time, number of 
      feeding episodes per day, total eating and drinking time, and the daily ratio of 
      food consumed to water consumed, CR also decreased average body temperature per 
      day, O2 consumption, CO2 production, and respiratory quotient. A variety of 
      parameters concerning water consumption were not affected. CR rats ate their food 
      immediately when food was presented during the light span, while ad libitum fed 
      animals ate numerous small meals throughout the entire dark span. An anticipatory 
      response to restricted feeding was also noted. Total motor activity, metabolism, 
      and body temperature increased just prior to scheduled feeding and reached 
      maximum values shortly after feeding, suggesting that these parameters were 
      highly synchronized to feeding. Females and males were found to respond to 
      caloric restriction in a similar fashion. Dramatic changes in respiratory 
      quotient and body temperature suggest rapid shifts between metabolic pathways 
      (glycolysis to gluconeogenesis) to obtain optimal efficiency. Lower body 
      temperature and metabolism may provide protection against DNA damage, thereby 
      increasing the survival potential of restricted rats. These responses may provide 
      insight into the mechanisms by which caloric restriction acts to extend life 
      span.
FAU - Duffy, P H
AU  - Duffy PH
AD  - Department of Health and Human Services, Food and Drug Administration, National 
      Centre for Toxicological Research, Jefferson, AR 72079.
FAU - Feuers, R
AU  - Feuers R
FAU - Nakamura, K D
AU  - Nakamura KD
FAU - Leakey, J
AU  - Leakey J
FAU - Hart, R W
AU  - Hart RW
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chronobiol Int
JT  - Chronobiology international
JID - 8501362
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Circadian Rhythm/*physiology
MH  - Drinking Behavior/physiology
MH  - Energy Intake
MH  - Energy Metabolism
MH  - Feeding Behavior/physiology
MH  - Female
MH  - *Food Deprivation
MH  - Longevity
MH  - Oxygen Consumption
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.3109/07420529009056963 [doi]
PST - ppublish
SO  - Chronobiol Int. 1990;7(2):113-24. doi: 10.3109/07420529009056963.