PMID- 22425898
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20181201
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 44
DP  - 2012 Sep
TI  - Number of persistent organic pollutants detected at high concentrations in a 
      general population.
PG  - 106-11
LID - 10.1016/j.envint.2012.02.005 [doi]
AB  - BACKGROUND: Surveys of human exposure to environmental chemicals do not integrate 
      the number of compounds detected per person and the concentration of each 
      compound. This leaves untested relevant exposure scenarios, such as whether 
      individuals with low concentrations of some compounds have high concentrations of 
      the other compounds. OBJECTIVE: To analyze the number of persistent organic 
      pollutants (POPs) detected at high concentrations. METHODS: Serum concentrations 
      of 19 POPs were analyzed by gas chromatography with electron-capture detection in 
      a representative sample of the general population of Catalonia, Spain (N=919). 
      RESULTS: Over 58% of participants had concentrations in the top quartile of >/=1 of 
      the eight most prevalent POPs, and 34% of >/=3 POPs. 83% of women 60 to 74 years 
      old had concentrations of >/=3 POPs in the top quartile; 56% of women 60 to 74 
      years had p,p'-DDE, HCB and beta-HCH all in their respective top quartiles, and 48% 
      had concentrations of >/=6 POPs in the top quartile. Over 30% of subjects had 
      concentrations in the top decile of 1 to 5 of the eight most prevalent POPs. Half 
      of the population had levels of 1 to 5 POPs >500 ng/g. Less than 4% had all eight 
      POPs in the lowest quartile. CONCLUSIONS: More than half of the study population 
      had concentrations in the top quartile of >/=1 POPs. Significant subgroups of the 
      population accumulate POP mixtures at high concentrations. POP concentrations 
      appear low in most of the population only when each individual compound is looked 
      at separately.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Porta, Miquel
AU  - Porta M
AD  - Hospital del Mar Research Institute-IMIM, Barcelona, Spain; School of Medicine, 
      Universitat Autonoma de Barcelona, Spain. mporta@imim.es
FAU - Pumarega, Jose
AU  - Pumarega J
FAU - Gasull, Magda
AU  - Gasull M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120315
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Dichlorodiphenyl Dichloroethylene/analysis/blood
MH  - Environmental Exposure/analysis/*statistics & numerical data
MH  - Environmental Pollutants/analysis/*blood
MH  - Environmental Pollution/*statistics & numerical data
MH  - Female
MH  - Hexachlorobenzene/analysis/blood
MH  - Hexachlorocyclohexane/analysis/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Spain
MH  - Young Adult
EDAT- 2012/03/20 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/03/20 06:00
PHST- 2011/12/21 00:00 [received]
PHST- 2012/01/28 00:00 [revised]
PHST- 2012/02/17 00:00 [accepted]
PHST- 2012/03/20 06:00 [entrez]
PHST- 2012/03/20 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - S0160-4120(12)00037-2 [pii]
AID - 10.1016/j.envint.2012.02.005 [doi]
PST - ppublish
SO  - Environ Int. 2012 Sep;44:106-11. doi: 10.1016/j.envint.2012.02.005. Epub 2012 Mar 
      15.