PMID- 22426166
OWN - NLM
STAT- MEDLINE
DCOM- 20140725
LR  - 20120319
IS  - 1735-367X (Electronic)
IS  - 1735-1383 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Mar
TI  - Association of KIR3DS1+HLA-B Bw4Ile80 combination with susceptibility to 
      tuberculosis in Lur population of Iran.
PG  - 39-47
AB  - BACKGROUND: Natural killer (NK) cells are the effector cells of innate immunity 
      that respond to infection and tumor. Interactions between killer cell 
      immunoglobulin like receptors (KIR) and human leukocyte antigen (HLA) class I 
      molecules regulate NK cells responses to eliminate infected and transformed 
      cells. OBJECTIVE: To investigate the impact of KIR genes, HLA ligand genes, and 
      KIR-HLA combinations on susceptibility to tuberculosis (TB) in Lur population of 
      Iran. METHODS: The genomic DNA of 50 patients with TB from Lorestan province of 
      Iran was genotyped for sixteen KIR genes and their five major HLA class I ligands 
      were determined by a polymerase chain reaction-sequence-specific primers 
      (PCR-SSP) assay. The results were compared with those of 200 healthy unrelated 
      Iranian individuals. RESULTS: In Lur population of Iran, a significant decrease 
      in frequency of KIR3DS1 was found in TB patients compared to control group (24% 
      vs. 44.5%, OR=0.394, CI=0.194-0.798, p=0.013). Also, among the three activating 
      genes that may use HLA class I molecules as their ligands, a significant decrease 
      was shown in frequency of KIR3DS1 with HLA-B Bw4Ile80 ligand in TB patients 
      compared to control group (4% vs. 23%, OR=0.14, CI=0.033-0.596, p=0.004). 
      CONCLUSION: These findings imply a genetic imbalance between activating and 
      inhibitory KIR genes and KIR-HLA combinations in Lur TB patients. Low level of 
      activating KIR3DS1 and its combination with HLA-B Bw4Ile80 ligand might have an 
      influence on the susceptibility to TB in Lur population of Iran.
FAU - Shahsavar, Farhad
AU  - Shahsavar F
AD  - Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran, 
      e-mail: tshabestari@sina.tums.ac.ir.
FAU - Mousavi, Tahereh
AU  - Mousavi T
FAU - Azargon, Alireza
AU  - Azargon A
FAU - Entezami, Kobra
AU  - Entezami K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Iran
TA  - Iran J Immunol
JT  - Iranian journal of immunology : IJI
JID - 101282932
RN  - 0 (DNA Primers)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-Bw4 antigen)
RN  - 0 (Receptors, KIR3DS1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - DNA Primers/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - Receptors, KIR3DS1/*genetics
MH  - Tuberculosis/*genetics
MH  - Young Adult
EDAT- 2012/03/20 06:00
MHDA- 2014/07/26 06:00
CRDT- 2012/03/20 06:00
PHST- 2012/03/20 06:00 [entrez]
PHST- 2012/03/20 06:00 [pubmed]
PHST- 2014/07/26 06:00 [medline]
AID - 03 [pii]
PST - ppublish
SO  - Iran J Immunol. 2012 Mar;9(1):39-47.