PMID- 22427774
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Print)
IS  - 1734-1922 (Linking)
VI  - 6
IP  - 6
DP  - 2010 Dec
TI  - Interleukin-18 expression and the response to treatment in patients with 
      psoriasis.
PG  - 964-70
LID - 10.5114/aoms.2010.19309 [doi]
AB  - INTRODUCTION: The aim of the study was to demonstrate Interleukin-18 (IL-18) 
      expression in keratinocytes from psoriatic lesions in comparison to keratinocytes 
      from uninvolved skin and to study the change of expression after therapeutic 
      interventions. MATERIAL AND METHODS: This study included 16 patients of different 
      clinical subtypes of psoriasis. IL-18 gene expression analysis was performed 
      using real-time quantitative PCR. Three biopsies were obtained from each patient. 
      Two were taken from the lesional psoriatic skin and from uninvolved skin before 
      starting treatment. A third lesional skin biopsy was taken at the end of two 
      months' treatment course. The treatment was in the form of topical steroids or 
      oral systemic methotrexate. RESULTS: Of all 16 studied patients significantly 
      increased IL-18 expression was noted in keratinocytes from psoriatic lesions 
      before and after treatment when compared to keratinocytes from uninvolved skin (P 
      = 0.001 and 0.002 respectively). The IL-18 expression in the skin lesions after 
      treatment was significantly lower than lesional skin before treatment (P = 
      0.023). In psoriatic skin lesions of all studied patients IL-18 expression was 
      significantly correlated with disease duration (r = 0.40 and P = 0.01) and 
      clinical severity of psoriasis (r = 0.72 and P = 0.001). CONCLUSIONS: Increased 
      IL-18 expression in keratinocytes from psoriatic lesions of our patients and its 
      correlation with disease duration and severity supported the concept which views 
      psoriasis as a T-cell-mediated autoimmune disease. This could establish 
      therapeutic and preventive approaches for psoriasis that ultimately lead to 
      improved outcomes for patients.
FAU - Mohamed Attia, Hanaa Rasmy
AU  - Mohamed Attia HR
AD  - Clinical and Chemical Pathology Department, National Research Center, Cairo, 
      Egypt.
FAU - Mikhael, Nancy
AU  - Mikhael N
FAU - Ismail, Somaia
AU  - Ismail S
LA  - eng
PT  - Journal Article
DEP - 20101229
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3302712
OTO - NOTNLM
OT  - effect of therapy
OT  - interleukins
OT  - psoriasis
OT  - real-time PCR
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
PMCR- 2010/12/01
CRDT- 2012/03/20 06:00
PHST- 2009/08/18 00:00 [received]
PHST- 2009/11/15 00:00 [revised]
PHST- 2010/02/22 00:00 [accepted]
PHST- 2012/03/20 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - AMS-6-6-964 [pii]
AID - 10.5114/aoms.2010.19309 [doi]
PST - ppublish
SO  - Arch Med Sci. 2010 Dec;6(6):964-70. doi: 10.5114/aoms.2010.19309. Epub 2010 Dec 
      29.