PMID- 22429366
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20191210
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Linking)
VI  - 40
IP  - 1
DP  - 2012
TI  - Alleviation of ferric chloride-induced seizures and retarded behaviour in 
      epileptic rats by cortical electrical stimulation treatment.
PG  - 266-81
AB  - OBJECTIVE: To study the effects of low-frequency cortical electrical stimulation 
      (CES) on seizures and behaviour in a rat model of epilepsy induced by ferric 
      chloride (FeCl3). METHODS: Rats were randomly assigned into four groups (n=8 per 
      group): normal healthy rats; saline-treated control rats; FeCl3-induced epileptic 
      rats; CES-treated FeCl3-induced epileptic rats. Behavioural tests, analysis of 
      the levels of brain-derived neurotrophic factor (BDNF) protein in brain tissue, 
      and ultrastructural studies using transmission electron microscopy (TEM) were 
      undertaken. RESULTS: CES significantly decreased the number and grade of 
      seizures, and improved rat behaviour, compared with untreated epileptic rats. CES 
      reduced levels of BDNF protein in the forebrain and increased levels of BDNF 
      protein in the hippocampus compared with untreated epileptic rats. TEM showed 
      less damage and ultrastructural changes in the neurons of CES-treated epileptic 
      rats. CONCLUSIONS: CES inhibited seizures in FeCl3-induced epileptic rats and 
      improved their behaviour. These effects might be mediated by altering BDNF 
      protein levels in the brain.
FAU - Wang, C
AU  - Wang C
AD  - Department of Neurosurgery, Tangdu Hospital, and Department of Biomedical 
      Engineering, Fourth Military Medical University, ShanXi, Xi'an, China.
FAU - Wu, H
AU  - Wu H
FAU - He, F
AU  - He F
FAU - Jing, X
AU  - Jing X
FAU - Liang, Q
AU  - Liang Q
FAU - Heng, G
AU  - Heng G
FAU - Wang, L
AU  - Wang L
FAU - Gao, G
AU  - Gao G
FAU - Zhang, H
AU  - Zhang H
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Chlorides)
RN  - 0 (Ferric Compounds)
RN  - U38V3ZVV3V (ferric chloride)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Cortex/pathology/*physiopathology/ultrastructure
MH  - Chlorides
MH  - Disease Progression
MH  - *Electric Stimulation Therapy
MH  - Electroencephalography
MH  - Ferric Compounds
MH  - Latency Period, Psychological
MH  - Male
MH  - Maze Learning
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seizures/chemically induced/*physiopathology/*therapy
MH  - Time Factors
EDAT- 2012/03/21 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/03/21 06:00
PHST- 2012/03/21 06:00 [entrez]
PHST- 2012/03/21 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - 10.1177/147323001204000127 [doi]
PST - ppublish
SO  - J Int Med Res. 2012;40(1):266-81. doi: 10.1177/147323001204000127.