PMID- 22430490
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20211203
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 209
IP  - 4
DP  - 2012 Apr 9
TI  - Characterization of resident and migratory dendritic cells in human lymph nodes.
PG  - 653-60
LID - 10.1084/jem.20111457 [doi]
AB  - Dendritic cells (DCs) initiate adaptive immune responses in lymph nodes (LNs). In 
      mice, LN DCs can be divided into resident and tissue-derived populations, the 
      latter of which migrate from the peripheral tissues. In humans, different subsets 
      of DCs have been identified in the blood, spleen, and skin, but less is known 
      about populations of resident and migratory tissue-derived DCs in LNs. We have 
      analyzed DCs in human LNs and identified two populations of resident DCs that are 
      present in all LNs analyzed, as well as in the spleen and tonsil, and correspond 
      to the two known blood DC subtypes. We also identify three main populations of 
      skin-derived migratory DCs that are present only in skin-draining LNs and 
      correspond to the DC subsets found in the skin. Resident DCs subsets induce both 
      Th1 and Th2 cytokines in naive allogeneic T lymphocytes, whereas the 
      corresponding blood subsets failed to induce efficient Th2 polarization. 
      LN-resident DCs also cross-present antigen without in vitro activation, whereas 
      blood DCs fail to do so. Among migratory DCs, one subset was poor at both CD4(+) 
      and CD8(+) T cell activation, whereas the other subsets induced only Th2 
      polarization. We conclude that in humans, skin-draining LNs host both resident 
      and migratory DC subsets with distinct functional abilities.
FAU - Segura, Elodie
AU  - Segura E
AD  - Institut National de la Sante et de la Recherche Medicale Unite 932, 75005 Paris, 
      France.
FAU - Valladeau-Guilemond, Jenny
AU  - Valladeau-Guilemond J
FAU - Donnadieu, Marie-Helene
AU  - Donnadieu MH
FAU - Sastre-Garau, Xavier
AU  - Sastre-Garau X
FAU - Soumelis, Vassili
AU  - Soumelis V
FAU - Amigorena, Sebastian
AU  - Amigorena S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120319
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Mannose Receptor)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Antigens, CD1/analysis
MH  - Cell Movement
MH  - Cell Polarity
MH  - Dendritic Cells/*immunology/physiology
MH  - Humans
MH  - Lectins, C-Type/analysis
MH  - Lipopolysaccharide Receptors/analysis
MH  - Lymph Nodes/*immunology
MH  - Mannose Receptor
MH  - Mannose-Binding Lectins/analysis
MH  - Receptors, Cell Surface/analysis
MH  - Skin/immunology
MH  - Th2 Cells/physiology
PMC - PMC3328358
EDAT- 2012/03/21 06:00
MHDA- 2012/06/05 06:00
PMCR- 2012/10/09
CRDT- 2012/03/21 06:00
PHST- 2012/03/21 06:00 [entrez]
PHST- 2012/03/21 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
PHST- 2012/10/09 00:00 [pmc-release]
AID - jem.20111457 [pii]
AID - 20111457 [pii]
AID - 10.1084/jem.20111457 [doi]
PST - ppublish
SO  - J Exp Med. 2012 Apr 9;209(4):653-60. doi: 10.1084/jem.20111457. Epub 2012 Mar 19.