PMID- 22430749
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20151119
IS  - 0034-1193 (Print)
IS  - 0034-1193 (Linking)
VI  - 103
IP  - 2
DP  - 2012 Feb
TI  - [Pemetrexed monotherapy in previously treated patients with advanced non small 
      cell lung cancer; differences by histology. Our experience].
PG  - 62-5
LID - 10.1701/1045.11387 [doi]
AB  - Emerging data suggest pemetrexed is active in patients with adenocarcinoma of 
      lung compared to those with squamous cell carcinoma. We retrospectively reviewed 
      advanced non small cell lung cancer (NSCLC) patients previously treated, 
      analysing efficacy on histologic characteristics. From January 2007 to December 
      2010, 25 patients with stage IIIB or IV NSCLC (17 with adenocarcinoma and 8 with 
      squamous cell carcinoma), who had previously failed on platinum-based 
      chemotherapy, received pemetrexed 500 mg/mq every 3 weeks until disease 
      progression or unacceptable toxicities. Analysing the histologic subgroups we 
      observed 1 (5.9%) complete response, partial response in 5 patients (29.4%), 
      stable disease in 6 (35.3%), progression disease in 5 (29.4%) in adenocarcinoma 
      group compared to 4 (50%) stable disease and 4 (50%) progression disease in 
      squamous cell carcinoma group. Median progression free survival was 8 months 
      (range 3-22) for adenocarcinoma patients and 4 months (range 2-6) for squamous 
      cell patients. According to data of the literature, also our small retrospective 
      study conducted on unselected patients confirms the difference of pemetrexed 
      efficacy by histology type, with better results in patients with adenocarcinoma 
      lung cancer.
FAU - Pistillucci, Giorgio
AU  - Pistillucci G
AD  - UO Oncologia Medica, Ospedale Santa Maria Goretti, Latina. 
      g.pistillucci@panservice.it
FAU - Sciacca, Venerina
AU  - Sciacca V
FAU - Ciorra, Alida
AU  - Ciorra A
FAU - Di Palma, Teresa
AU  - Di Palma T
FAU - Calabretta, Francesca
AU  - Calabretta F
FAU - Lugini, Antonio
AU  - Lugini A
FAU - Rossi, Rosalinda
AU  - Rossi R
FAU - D'Aprile, Modesto
AU  - D'Aprile M
FAU - Veltri, Enzo
AU  - Veltri E
LA  - ita
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Monoterapia con pemetrexed in pazienti pretrattati affetti da carcinoma polmonare 
      non a piccole cellule in fase avanzata: impatto dell'istologia. Nostra 
      esperienza.
PL  - Italy
TA  - Recenti Prog Med
JT  - Recenti progressi in medicina
JID - 0401271
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Glutamates)
RN  - 04Q9AIZ7NO (Pemetrexed)
RN  - 5Z93L87A1R (Guanine)
SB  - IM
MH  - Adenocarcinoma/drug therapy
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/*therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy/mortality/pathology
MH  - Carcinoma, Squamous Cell/drug therapy
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Glutamates/*therapeutic use
MH  - Guanine/*analogs & derivatives/therapeutic use
MH  - Humans
MH  - Lung Neoplasms/*drug therapy/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Pemetrexed
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2012/03/21 06:00
MHDA- 2012/05/12 06:00
CRDT- 2012/03/21 06:00
PHST- 2012/03/21 06:00 [entrez]
PHST- 2012/03/21 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - 10.1701/1045.11387 [doi]
PST - ppublish
SO  - Recenti Prog Med. 2012 Feb;103(2):62-5. doi: 10.1701/1045.11387.