PMID- 22431250
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 34
IP  - 8
DP  - 2013 Aug
TI  - Altered resting-state connectivity during interictal generalized spike-wave 
      discharges in drug-naive childhood absence epilepsy.
PG  - 1761-7
LID - 10.1002/hbm.22025 [doi]
AB  - PURPOSE: To investigate the intrinsic brain connections at the time of interictal 
      generalized spike-wave discharges (GSWDs) to understand their mechanism of effect 
      on brain function in untreated childhood absence epilepsy (CAE). METHODS: The 
      EEG-functional MRI (fMRI) was used to measure the resting state functional 
      connectivity during interictal GSWDs in drug-naive CAE, and three different brain 
      networks-the default mode network (DMN), cognitive control network (CCN), and 
      affective network (AN)-were investigated. RESULTS: Cross-correlation functional 
      connectivity analysis with priori seed revealed decreased functional connectivity 
      within each of these three networks in the CAE patients during interictal GSWDS. 
      It included precuneus-dorsolateral prefrontal cortex (DLPFC), dorsomedial 
      prefrontal cortex (DMPFC), and inferior parietal lobule in the DMN; 
      DLPFC-inferior frontal junction (IFJ), and pre-supplementary motor area (pre-SMA) 
      subregions connectivity disruption in CCN; ACC-ventrolateral prefrontal cortex 
      (VLPFC) and DMPFC in AN; There were also some regions, primarily the 
      parahippcampus, paracentral in AN, and the left frontal mid orb in the CCN, which 
      showed increased connectivity. CONCLUSIONS: The current findings demonstrate 
      significant alterations of resting-state networks in drug naive CAE subjects 
      during interictal GSWDs and interictal GSWDs can cause dysfunction in specific 
      networks important for psychosocial function. Impairment of these networks may 
      cause deficits both during and between seizures. Our study may contribute to the 
      understanding of neuro-pathophysiological mechanism of psychosocial function 
      impairments in patients with CAE.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Yang, Tianhua
AU  - Yang T
AD  - Department of Neurology, West China Hospital, Si Chuan University, Cheng du, 
      Sichuan, People's Republic of China.
FAU - Luo, Cheng
AU  - Luo C
FAU - Li, Qifu
AU  - Li Q
FAU - Guo, Zhiwei
AU  - Guo Z
FAU - Liu, Ling
AU  - Liu L
FAU - Gong, Qiyong
AU  - Gong Q
FAU - Yao, Dezhong
AU  - Yao D
FAU - Zhou, Dong
AU  - Zhou D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120319
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Brain/*physiopathology
MH  - *Brain Mapping
MH  - Child
MH  - Child, Preschool
MH  - Electroencephalography
MH  - Epilepsy, Absence/*physiopathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Rest/physiology
PMC - PMC6870260
OTO - NOTNLM
OT  - CAE
OT  - EEG-fMRI
OT  - functional connectivity
OT  - interictal GSWDs
OT  - resting state
EDAT- 2012/03/21 06:00
MHDA- 2014/03/07 06:00
PMCR- 2012/03/19
CRDT- 2012/03/21 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/11/17 00:00 [revised]
PHST- 2011/11/29 00:00 [accepted]
PHST- 2012/03/21 06:00 [entrez]
PHST- 2012/03/21 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
PHST- 2012/03/19 00:00 [pmc-release]
AID - HBM22025 [pii]
AID - 10.1002/hbm.22025 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2013 Aug;34(8):1761-7. doi: 10.1002/hbm.22025. Epub 2012 Mar 19.